A recent study from the Pharmacology Institute, University of Heidelberg, Heidelberg, Germany; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA shows that the Serine protease inhibitor-A3N attenuates neuropathic pain by inhibiting T cell–derived leukocyte elastase. This study was published in the 27 April 2015 issue of the Journal “Nature Medicine” (the no.1 journal in General medicine with an impact factor of >28) by Prof.Dr. Kuner, Vicuna and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Steroid–based neuropathic pain relieving therapy: Testosterone inhibits neuropathic pain via down regulation of T cell–derived leukocyte elastase.
The mechanistic basis of Neuropathic pain is far from clear. This study suggests that, Testosterone, by increasing the expression of its target gene, it may decrease the expression of T cell–derived leukocyte elastase. Thereby, it may relieve neuropathic pain. Thus, pharmacological formulations encompassing “Testosterone or its analogues“ may be used to inhibit Neuropathic pain.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, Steroid-based neuropathic pain relieving therapy: Testosterone inhibits neuropathic pain via down regulation of T cell–derived leukocyte elastase, 7/May/2015, 15.25, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Courtesy: When you cite drop us a line at email@example.com
Undisclosed information: How Testosterone decreases the expression of T cell–derived leukocyte elastase
* Research cooperation