A recent study from the Pharmacology Institute, University of Heidelberg, Heidelberg, Germany; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA shows that the Serine protease inhibitor-A3N attenuates neuropathic pain by inhibiting T cell–derived leukocyte elastase. This study was published in the 27 April 2015 issue of the Journal “Nature Medicine” (the no.1 journal in General medicine with an impact factor of >28) by Prof.Dr. Kuner, Vicuna and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Steroid–based neuropathic pain relieving therapy: Testosterone inhibits neuropathic pain via down regulation of T cell–derived leukocyte elastase.
Significance:
The mechanistic basis of Neuropathic pain is far from clear. This study suggests that, Testosterone, by increasing the expression of its target gene, it may decrease the expression of T cell–derived leukocyte elastase. Thereby, it may relieve neuropathic pain. Thus, pharmacological formulations encompassing “Testosterone or its analogues“ may be used to inhibit Neuropathic pain.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Steroid-based neuropathic pain relieving therapy: Testosterone inhibits neuropathic pain via down regulation of T cell–derived leukocyte elastase, 7/May/2015, 15.25, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Testosterone decreases the expression of T cell–derived leukocyte elastase
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