Introduction: What they say:
A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published, in the 30 September 2011 issue of the Journal “Cell” [One of the best journals in Biological sciences with an I.F of 28.71], by Prof and Dean of the Harvard Medical School George Q, Zhu H, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanical Stretch therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Mechanical Stretch therapy increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target gene Lin28
From significance of the study to Public health relevance:
Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) Diabetes is going to be one of the top 10 causes of death by 2030; (3) the life-long painful injection/drug treatment is required to treat DM; (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells and cardiomyocytes that were lost in DM (Diabetes Mellitus) and MI (Myocardial infarction), respectively; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.
What is known?
Prof. George Q’s research team members had shown earlier that loss of Lin28 in muscles promotes insulin resistance and glucose intolerance.
From Research findings to Therapeutic opportunity:
Although mechanical stretch/stretch exercises/strech therapy has long been believed to improve diabetic and cardiac patients, the mechanism of action is lacking.
This study suggests, for the first time, that Mechanical stretch, by increasing the expression of its target genes, it may (1) increase the expression of IGF1R, INSR, and IRS2; (2) enhance tissue repair; (3) promote regeneration of pancreatic β-cells; (3) augment regenerative capacity; (4) promote insulin sensitivity; and (5) protect against dilated cardiomyopathy (DCM) (Fig.1).
Figure 1. Mechanistic insights into how Mechanical stretch may aid in amelioration of insulin resistance and myocardial infarction. Mechanical stretch may promote insulin sensitivity and protect against myocardial infarction via up regulation of reprogramming protein Lin-28 and other genes.
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Thus, by encouraging diabetic/cardiac patients to undergo stretch therapy, one may improve pancreatic/cardiac function, and prevent diabetes and ageing-associated (or, stress-associated) decline in cardiac/pancreatic function (Fig.2). Together, this study suggests, for the first time, that diabetologists/cardiologists may consider recommending their patients suffering from diabetes/dilated cardiomyopathy to undergo stretch therapy.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $ 100#
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Undisclosed mechanistic information: How does stretch therapy promote insulin-sensitized state?
# Research cooperation
References:
Web: http://genomediscovery.org or http://newbioideas.com/
Citation: Boominathan L, Mechanical Stretch therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Mechanical Stretch therapy increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target gene Lin28, 24/May/2017, 7.26 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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