A recent study from the Department of Preventive Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China; and Department of Periodontics, School of Dental Medicine, Philadelphia shows that “FOXO1 differentially regulates both normal and diabetic wound healing.” This study was published in the 27 April 2015 issue of Journal of Cell Biology (JCB) by Prof Dana T. Graves & Chenying Zhang, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Sunlight exposure enhances wound healing in Diabetic patients: Cholecalciferaol accelerates wound closure in diabetic patients via down regulation of its target gene
Significance:
This study suggests a small molecule-based wound healing therapy for diabetic patients. Cholecalciferaol, by increasing the expression of its target gene, it may: (1) increase TGF-β1 expression and its down stream target genes; (2) increase keratinocyte migration; and (3) promote wound closure. Thereby, it may accelerate wound healing. Thus, pharmacological formulations encompassing “Cholecalciferaol or its analogues” may be used to accelerate would healing. Given that exposure to Sunlight increases the levels of 1,25-dihydroxyvitamin D, Diabetic patients may expose to the optimal level of sunlight to accelerate wound healing.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Sunlight exposure enhances wound healing in Diabetic patients: Cholecalciferaol accelerates wound closure in diabetic patients via down regulation of its target gene, 13/May/2015, 11.15 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Cholecalciferaol accelerates wound healing in diabetic patients
