Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Significance: This study suggests a vitamin-based Anti-metastasis therapy. 1α, 25-dihydroxyvitamin D3 (Calcitriol), by increasing the expression of its target genes, it may increase the expression of tumor suppressor Sprouty-1. Thereby, it may inhibit migration and invasion of metastatic cancer cells. Thus, pharmacological formulations encompassing ” Calcitriol or its analogues” may be used to inhibit the progression of invasive tumors. Given that exposure to Sunlight increases the levels of 1,25-dihydroxyvitamin D, one may expose to the optimal level of sunlight to stall cancer progression.
Undisclosed information: How Calcitriol increases the expression of Sprouty-1
Citation: Boominathan, L., Sunlight exposure stalls metastatic cancer progression: Calcitriol (1α, 25-dihydroxyvitamin D3) increases the expression of tumor suppressor Sprouty-1 and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 16/April/2015, 23.42, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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