Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., T2DM drugs function as anti-metastatic agents: Acarbose, the widley used drug in the treatment of T2DM, suppresses the expression of actin-regulatory proteins FHOD1 and PPM1F and inhibits migration and invasion of metastatic cancer cells via up regulation of its target gene, 26/March/2015, 23.57, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: We have published earlier stating that the T2DM drug Metformin functions as an anti-metastatic agent. The study presented here suggests that Acarbose, by increasing the expression of its target genes, it may suppress the expression of actin-regulatory proteins FHOD1 and PPM1F. Thereby, it may inhibit migration and invasion of metastatic cancer cells. Thus, pharmacological formulations encompassing “Acarbose or its analogues” may be used to inhibit the progression of invasive tumors.
Undisclosed information: How Acarbose decreases the expression of FHOD1 and PPM1F
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