The Nobel Prize Winner in Physiology or Medicine (2012), Gurdon JB from Wellcome Trust/Cancer Research Gurdon Institute, Cambridge, UK reports in the prestigious journal Science that Nuclear Wave1 is required for reprogramming transcription in oocytes and for normal development. Based on this remarkable finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that the tumor suppressor gene p53/p63/p73 regulates the expression of Wave1 through its target genes. Furthermore, Dr Boominathan identifies the mechanism through which p53 and its homologues p63 and p73 regulate the maternal reprogramming factor Wave1. This exciting finding explains how stress induced p53 may cause abnormal development. Therefore, Dr Boominathan believes that this finding has great clinical utility.
Idea Proposed by: Dr L Boominathan Ph.D.
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To cite: Boominathan, The tumor suppressor gene p53/p63/p73 regulates the expression of Wave1 through its target genes, 24/September/2013, 20.42, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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