A recent study from the Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany shows that “RIPK1 maintains epithelial homeostasis by inhibiting apoptosis …“
This study was published in the August 17 2014 issue of Nature (The number 1 journal in Science with an I.F of 42) by Prof Manolis Pasparakis, Marius Dannappel and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Therapeutic insights into tissue homeostasis and inflammation: Triptolide, a natural compound found in the herb Thunder of God vine, maintains intestinal epithelial cell homeostasis via up regulation of RIPK1. Triptolide, by decreasing the expression of its target gene in intestinal cells, it may increase the expression of RIPK1. Thereby, it may prevent intestinal inflammation and inhibit apoptosis. Together, this study suggests that pharmacological formulations encompassing “Triptolide or its analogues” may be used to inhibit intestinal inflammation.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Therapetic insights into tissue homeostasis and inflammation: Triptolide, a natural compound found in the herb Thunder of God vine, maintains intestinal epithelial cell homeostasis via up regulation of RIPK1, 09/September/2014, 07.04 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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