A study from the Division of Oncology, Department of Medicine/Pathology, Stanford University, Stanford, California, USA shows that “MYC through miR-17-92 Suppresses Specific Target Genes to Maintain Survival, Autonomous Proliferation…”
This study was published in the August 11, 2014 issue of Cancer Cell (The number 1 journal in basic cancer biology with an IF: ~27.238) by Prof. Felsher, Li, and others from the Division of Oncology, Department of Medicine/Pathology, Stanford University, Stanford, California, USA.
On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Therapeutic and Mechanistic insights into tumor suppression: BMP-4 (Bone Morphogenetic protein-4) inhibits tumorigenesis via up regulation of Sin3b, Hbp1, Suv420h1, Btg1 & BIM. This study suggests, for the first time, that BMP-4, by up regulating its target gene, it may suppress the cancerous state of cells. Thereby, it may inhibit tumorigenesis. Together, this study suggests that pharmacological formulations encompassing “BMP4 or its activators” may be used to treat c-myc-overexpressing tumors.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Therapeutic and Mechanistic insights into tumor suppression: BMP-4 (Bone Morphogenetic protein-4) inhibits tumorigenesis via up regulation of Sin3b, Hbp1, Suv420h1, Btg1 & BIM., Genome-2-Bio-Medicine Discovery center (GBMD), 22/08/2014, 8.09 am, http://genomediscovery.org
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