A study from the Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA shows that “ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.“
This study was published in the August 3, 2014 issue of Nature Cell Biology by Prof. Li Ma, Zhang P and others from the Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Therapeutic insights into enhancing the radiosensitivity of tumor cells: Tumor suppressor Menin (MEN1) enhances radiosensitivity of tumor cells via down regulation of ATM and ZEB1. This study suggests that Menin1, by up regulating its target gene, it may suppress the expression of ATM and ZEB1. Thereby, it may enhance the radiosensitivity of tumor cells. Together, this study suggests that pharmacological formulations encompassing “Menin1 or its activators” may be used to treat radioresistant tumors.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, L., Therapeutic insights into enhancing the radiosensitivity of tumor cells: Tumor suppressor Menin (MEN1) enhances radiosensitivity of tumor cells via down regulation of ATM and ZEB1, Genome-2-Bio-Medicine Discovery center (GBMD), 14/08/2014, 21.39, http://genomediscovery.org
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