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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Therapeutic insights into the inhibition of hippocampal neurodegeneration and memory loss: MiRNA-125 promotes survival of hippocampal neurons and inhibits memory loss via down regulation of its target gene, 12/September/2014, 16.56, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Significance: This study suggests, for the first time, that miRNA-125 inhibits hippocampal neurodegeneration and memory loss. It has earlier been shown that miRNA-125 suppresses the expression of a number of stress activated genes.  Thus, pharmacological formulations encompassing “miRNA-125 or small molecule compounds that activate the expression of miR-125” may be used to treat neurodegenerative disorders, including amnesia.

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