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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Natural product-based therapy for amyotrophic lateral sclerosis:  Fisetin, a flavonoid enriched in strawberries, Mangoes and Cucumber, ameliorates amyotrophic lateral sclerosis via up regulation of HSF1/HSP70i chaperone, 29/September/2014, 06.08 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Significance: This study suggests that Fisetin, by increasing the expression of its target gene, it may increase the expression of HSF1/HSP70i chaperone.  Thereby, it may inhibit the development of amyotrophic lateral sclerosisThus, this study suggests that pharmacological formulations encompassing Fisetin or its analogues may be used to inhibit the disease pathology of amyotrophic lateral sclerosis. 

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