Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Therapeutic insights into the treatment of Fibrosis: 1,25-dihydroxyvitamin D inhibits pulmonary fibrosis via up regulation of its target gene, 27/September/2014, 06.15 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests that 1,25-dihydroxyvitamin D, by increasing the expression of its target gene, it may decrease the expression of a number of extracellular matrix genes. Thereby, it may inhibit the progression of pulmonary fibrosis. Thus, this study suggests that pharmacological formulations encompassing “1,25-dihydroxyvitamin D or its analogues” may be used to inhibit the progression of fibrotic diseases.