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A recent study from the Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, Lincoln’s Inn Fields Laboratories, London, United Kingdom; and School of Medicine, King’s College London, London, United Kingdom shows that “Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells.” This study was published in the August 7  2014 Cell Stem Cell by Prof Axel Behrens, Rocio Sancho, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:Therapeutic insights into the treatment of NIDDM/T2D: ING1b decreases reprogramming of adult pancreatic ductal cells into α, δ, and β cells via down regulation of Ngn3. This study suggests that ING1bby decreasing the expression of Ngn3 in adult pancreatic ductal cells, it may inhibit the reprograming of adult pancreatic ductal cells into β cells.  Thereby, it may decrease the expression of ING1b, and reduce insulin secretion and insulin sensitivity. Together, this study suggests that pharmacological formulations encompassingING1b inhibitors” may be used to treat stress-induced NIDMM

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Therapeutic insights into the treatment of NIDDM/T2D: ING1b decreases reprogramming of adult pancreatic ductal cells into α, δ, and β cells via down regulation of Ngn3, 19/August/2014,  10.26 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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