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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Therapeutic insights into the treatment of Sickle cell disease and β-thalassemias: Ras Responsive Element Binding Protein 1 (RREB) decreases sickling of erythrocytes via up regulation of fetal HbF, 25/September/2014, 06.41 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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SignificanceThis study suggests that RREBby regulating the expression of its target gene, it  may increase the levels of HbF.  Thus, pharmacological formulations encompassing “RREB activator” may be used to treat: (1) Sickle cell disease ;  (2) β-thalassemiasand (3) disease conditions that has lower levels of HbF

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