A recent study from the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, China shows that “SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain.” This study was published in the 8 October issue of 2014 Nature Communications by Prof Chen YH, Li J, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Therapeutic insights into the treatment of Stress-induced heart failure: Prolonged stress-induced p53 mediates heart failure via down regulation of SNX13.
Significance: This study suggests, for the first time, that p53, by increasing the expression of its target genes, it may decrease the expression of Sorting nexin-13 (SNX13). This may result in activation of the apoptotic pathway in cardiac cells and heart failure. This finding may suggest that decreasing the expression of p53 in cardiomyocytes will result in increased expression of SNX13. Together, this study suggests that pharmacological formulations encompassing “p53 inhibitor or SNX13 activator” may be used to treat myocardial disorders.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Therapeutic insights into the treatment of Stress-induced heart failure: Prolonged stress-induced p53 mediates heart failure via down regulation of SNX13, 14/October/2014, 14.54, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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