A study from the Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA has reported that excessive TGF-β signaling is a common mechanism in osteogenesis imperfecta.
This study was published in the 04 May 2014 Nature Medicine (IF-24.3) by Prof. Brendan Lee, Dr Ingo Grafe and others from Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA; Department of Orthopaedic Surgery, University of Texas Health Science Center at Houston, Houston, Texas, USA etc.
On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Treating brittle bones, fractures and extraskeletal manifestations with a Diapetic pill: Metformin, a widely used drug for TIIDM, ameliorates osteogenesis imperfecta via up regulation of its target gene
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Treating brittle bones, fractures and extraskeletal manifestations with a Diapetic pill: Metformin, a widely used drug for TIIDM, ameliorates osteogenesis imperfecta (OI) via up regulation of its target gene, 26/May/2014, 9.56 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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