Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Treating human tumors with PTEN activators: MiRNA miR-335 increases the expression of tumor suppressor PTEN via up regulation of its target gene. This data suggests that miR-335, by suppressing the expression of its down steam target gene, it will increase the expression of tumor suppressor PTEN. Given that tumor suppressor p53 is mutated in more than 50% of different human cancers, this study suggests, for the first time, a therapeutic strategy as to how mutant p53 expressing human cancer can be cured by activating an alternative tumor suppressor gene such as PTEN.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan,Treating human tumors with PTEN activators: MiRNA miR-335 increases the expression of tumor suppressor PTEN via up regulation of its target gene, 3/June/2014, 6.01 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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