A recent study from the Key Laboratory of Gene Engineering of the Ministry of Education, Key Laboratory of Reproductive Medicine of Guangdong Province, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510275, China shows that “Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression.” This study was published in the 6 March 2015 issue of the Journal “Aging Cell” (the no.1 journal in the field of Aging) by Prof. Songyang Z., Dr. Luo Z and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Turning on senescence turns off cancer progression: Curcumin, the major component of turmeric, induces telomere dysfunction and senescence via down regulation of Telomeric repeat binding factor 2 (TRF2). Thus, pharmacological formulations encompassing “Curcumin or its analogues” may be used to treat patients suffering from cancer.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Turning on senescence turns off cancer progression: Curcumin, the major component of turmeric, induces telomere dysfunction and senescence via down regulation of Telomeric repeat binding factor 2 (TRF2), 17/March/2015, 15.40, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Curcumin suppresses the expression of TRF2
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