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Noble Laureate Prof. David Baltimore (USA) has reported in the Journal Immunology ( J Immunol. 2011 Nov 15;187(10):5062-8) that  miRNAs play a significant role in stimulating  Mф/Immune cell activation.  In connection with this study, here, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports that ATRA (Vitamin A) decreases IFN regulatory factor 4 (IRF4) expression via up regulation of its target gene.  Thereby, ATRA (Vitamin A) augments  Mф/Immune cell activation. Together, this study suggests that Vitamin-A can be used to augment immune cell activation. 

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To citeBoominathan, L, Vitamin-mediated Mф/Immune cell activation: ATRA (Vitamin A) decreases IFN regulatory factor 4 (IRF4) expression via up regulation of its target gene, 7/December/2013, 5.49 am Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

* Research cooperation


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