Figure 1. Annato bixaorellana. Delta-tocotrienol is enriched in Annato bixaorellana.
From Research findings to Therapeutic opportunity:
The study presented here suggests that δ-tocotrienol, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; (ii) decrease BMI1 translocation; (iii) increase tumor suppressor INK4a/p16 expression; and (iv) restore chemosensitivity in drug-resistant Human cancers (Fig 1.).
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Thereby, it may: (1) inhibit proliferation; (2) decrease chemoresistance; and (3) promote apoptosis of cancer cells. Thus, pharmacological formulations encompassing “δ-tocotrienol or its analogues or δ-tocotrienol in combination with any of the known anti-cancer drugs” (fig. 2) may be used to inhibit drug-resistant cancer progression.
Figure 2. Delta-tocotrienol (A form of Vitamin-E)
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Undisclosed information: How δ-tocotrienol increases the expression of CADM1, and INK4a/p16?
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References:
Citation: Boominathan, L., Vitamin therapy for overcoming chemoresistance in Human cancers: δ-tocotrienol (a form of Vitamin-E) increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 4/January/2016, 12.15 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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