Monthly Archives :

October 2017

Molecular therapy for Non-alcoholic fatty liver disease (NAFLD): Isoflurane [Trade name: Forane] promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 09/October/2017, 11.10 am
Molecular therapy for Non-alcoholic fatty liver disease (NAFLD): Isoflurane [Trade name: Forane] promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 09/October/2017, 11.10 am 960 720 Dr Boomi's Genom-2-Discovery Center

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while only 6-25% of Asian populations suffer from it; (2) 75 to 100 million…

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Natural product-derived therapy for Stroke: Methysticin, isolated from Kava Kava, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via up regulation of its target genes BDNF and NAMPT, 9/October/2017, 1.25 am
Natural product-derived therapy for Stroke: Methysticin, isolated from Kava Kava, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via up regulation of its target genes BDNF and NAMPT, 9/October/2017, 1.25 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public…

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Natural product-based therapy for TIIDM and obesity-associated metabolic deficits: Yangonin, isolated from Kava Kava, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 9/October/2017, 1.18 am
Natural product-based therapy for TIIDM and obesity-associated metabolic deficits: Yangonin, isolated from Kava Kava, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 9/October/2017, 1.18 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent suppression of appetite…

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Natural product-based therapy for Metabolic diseases: Kavin, isolated from Kava Kava/Piper Methysticum, increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene.., 09/October/2017, 1.11 am
Natural product-based therapy for Metabolic diseases: Kavin, isolated from Kava Kava/Piper Methysticum, increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene.., 09/October/2017, 1.11 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland shows that “MicroRNAs 103 and 107 regulate insulin sensitivity.” This study was published, in the June 8, 2011 Nature [One of…

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Lifespan extension therapy: Glimpride, an anti- hyperglycemic medication, increases life span via up-regulation of its target gene BubR1, 8/October/2016, 11.59 pm
Lifespan extension therapy: Glimpride, an anti- hyperglycemic medication, increases life span via up-regulation of its target gene BubR1, 8/October/2016, 11.59 pm 960 720 Dr Boomi's Genom-2-Discovery Center

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School…

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Natural product-derived combination therapy for blood-stage Plasmodium infection: A therapeutic mix encompassing Clindamycin, Artemisinin, Doxycyclin, and Quinidine [CADQ]  decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via up regulation of its target gene, 8/October/2017, 11.55 pm
Natural product-derived combination therapy for blood-stage Plasmodium infection: A therapeutic mix encompassing Clindamycin, Artemisinin, Doxycyclin, and Quinidine [CADQ]  decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via up regulation of its target gene, 8/October/2017, 11.55 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that “Regulatory T cells impede…

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