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 Total no of Ideas: 10668 
August 17, 2018

A Relaxin(g)-way to say no to cardiac diseases: Relaxin-based therapy for attenuating pathogenesis-associated with Myocardial infarction: Relaxin, a reproductive hormone,  decreases IRF3 (Interferon regulatory transcription factor-3), GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival, via up-regulation of its target gene, 18/August/2018, 1.11 am

Introduction: What they say: A recent study from Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA; and Cardiovascular Research Center, Massachusetts General Hospital and […]
August 17, 2018

Unknown function of the known steroid hormone in targeting cancer stem cells in Myeloid leukaemia (ML): Progesterone (P4), a steroid hormone, inhibits cytosolic aminotransferase BCAT1 expression, increases a-ketoglutarate levels, promotes degradation of HIF1a levels, increases DNA demethylase levels, promotes hypomethylation, increases the expression of tumor suppressor genes, inhibits leukaemia-initiating potential of AML cells, promotes differentiation of AML cells, and inhibits cancer progression in AML via up-regulation of its target gene, 18/August/2017, 12.31 am

Introduction to what they say: A study from the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem […]
August 17, 2018

The contraceptive/birth control pill component Progestin may extend lifespan and healthspan: Progestin, one of the components of contraceptives and birth control pills, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target gene, 18/August/2017, 12.14 am

What they say:  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
August 17, 2018

Relax (in) your way to say no to myocardial diseases: Relaxin-based therapy for cardiac repair and myocardial infarction: Relaxin, a reprodutive hormone,  increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 17/August/2018, 11.59 pm

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, […]
August 17, 2018

Unknown function of the known reproductive hormone Progesterone (P4) in Anti-metastasis therapy: Progesterone (P4), an endogenous steroid hormone, inhibits the expression of a number of enzymes in the glycolytic cycle and suppresses proliferation, migration, invasion, tumorigenesis, and metastasis, via upregulation of its target gene, 17/August/2018, 11.45 am

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen […]
August 17, 2018

A drug used to treat angina may lengthen lifespan: Ranolazine-based therapy for life-span extension: Ranolazine (trade name: Ranexa) may  increase insulin sensitivity, slow down cardiac aging, and increase lifespan, via up-regulation of BubR1 and others genes, 17/August/2018, 11.36 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]
August 17, 2018

Relax(in) your way to keep the cardiac diseases at bay: Relaxin-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients:  Relaxin, a reproductive hormone,  increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down-regulation of its target gene, 17/August/2018, 11.19 pm

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
August 17, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  TIMP3, CCM3/KRIT1, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 17/August/2018, 10.55 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
August 14, 2018

Combinatorial therapy for Metastatic ovarian cancers: A therapeutic mix encompassing Salinomycin, Amitriptyline, Temozolomide, Berberine, Rosuvastatin, Carboplatin, Paclitaxel, and 17-DMAG (SATBRCPD) inhibits the expression of FABP4, increases the expression of a number of tumor suppressor genes, and stifles the metastatic potential and the progression of ovarian cancers, via up-regulation of its target gene, 14/August/2017, 8.37 am

Introduction: What they say: A study from the Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, […]
August 13, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  TPM1, INK4a/ARF, TA-p73, TA-p63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 13/August/2018, 10.41 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
August 13, 2018

Contraceptive pills may aid in the treatment of blood-stage Plasmodium infection: Progestin, one of the components of birth control/contraceptive pills, decreases the expression of CTLA-4, PD-L1, and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via upregulation of its target gene, 13/August/2018, 6.52 pm

Introduction: What they say A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that […]
August 13, 2018

An aspirin a day keeps HIV1-infections at bay: Aspirin, an analgesic/antipyretic drug, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via upregulation of its target gene, 13/August/2018, 6.28 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: An aspirin a day keeps HIV1-infections at bay: Aspirin, an analgesic/antipyretic drug, increases Heme […]

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Dr Boominathan’s quote on Science

Science is not about how to follow the conventions, but about how not to follow the conventions