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 Total no of Ideas: 10605 
July 23, 2018

Repurposing tuberculosis vaccine into a diabetic vaccine: TB/BCG vaccine, a tuberculosis vaccine, decreases DNA-PPK expression, suppresses phosphorylation of HSP90a, increases AMPK activity, augments mitochondrial biogenesis and energy metabolism, promotes weight loss and exercise endurance and alleviates TIIDM via down-regulation of its target gene, 23/July/2018, 11.14 am

Introduction: What they say A study from the Laboratory of Obesity and Aging Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD […]
July 23, 2018

Flu vaccine-based therapy for TIIDM and obesity-associated metabolic deficits: Influenza A (H1N1)/Flu vaccine increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down-regulation of its target gene, 23/July/2018, 11.01 am

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent […]
July 22, 2018

Molecular therapy for Cardiomyopathy: Nucleolin, a phosphoprotein found in Nucleolus, decreases the expression of Sox6, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via upregulation of its target gene, 22/July/2018, 9.48 pm

Introduction: What they say   A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart […]
July 22, 2018

 Polysaccharide-based anti-infective Therapy: Astragalus polysaccharide, isolated from astragalus membraneous, inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 22/July/2018,  5.41 pm

Introduction: What they say: A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA […]
July 22, 2018

Reproductive hormone aids in control of body weight, energy homeostasis and TIIDM: FSH(Follicle stimulating hormone), a polypeptide glycoprotein, decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 22/July/2017, 5.31 pm

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by […]
July 20, 2018

Molecular therapy for aging-associated diseases and Lifespan extension: Enoxacin, a broad-spectrum antibacterial agent, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down-regulation of its target gene, 20/July/2018, 11.27 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
July 20, 2018

Antiviral therapy for Neuroinvasive West Nile virus: β-(1,3)-glucan/Lentinan(LNT), isolated from mushroom Lentinus edodes, increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via upregulation of its target gene, 20/July/2018, 1.51 pm

Introduction: What they say A study from the Department of Immunology, University of Washington, Seattle, WA 98109, USA; Center for Innate Immunity and Immune Disease, University of […]
July 20, 2018

Repurposing the H.Pylori vaccine CTB-UE into a pulmonary arterial hypertension (PAH) vaccine: CTB-UE, a Helicobacter Pyroli vaccine, inhibits the development of pulmonary arterial hypertension via down-regulation of its target gene Notch3, 20/July/2018, 1.22 pm

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November  2009 issue of the journal “Nature Medicine“[the number […]
July 20, 2018

Flu vaccine for normalizing blood sugar levels: Influenza A/Flu (H1N1) vaccine-based therapy for blood sugar disease: Influenza A/Flu (H1N1) vaccine increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 20/July/2018, 9.39 am

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]
July 20, 2018

Flu vaccine preserves your eyes against glaucoma:  Influenza A/Flu (H1N1) vaccine-based therapy for glaucoma: Influenza A/Flu (H1N1) vaccine increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma,  via down-regulation of its target gene, 20/July/2018,   9.05 am

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, […]
July 18, 2018

Flavonoid your way to decrease blood pressure/sugar and extend lifespan: Quercetin-based Lifespan and healthspan extension therapy: Quercetin,  a flavonoid isolated from elder berries and onions, decreases blood sugar and blood pressure levels and prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 18/July/2018, 7.47 am

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown […]
July 18, 2018

Heat-shock inhibitors (HSPs) as longevity-promoters: HSP-90 inhibitor-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing 17-DMAG(HSP-90 inhibitor), Ursolic acid, Catalpol, Isoliquiritigenin, Maresin, DIM, Lutein, Maresin, Cholecalciferol (17-DMAGUCIMDLMC) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan, via up regulation of its target gene ATG5 (Autophagy related 5), 18/July/2018, 7.34 am

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was […]

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