Genome Discovery

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 Total no of Ideas: 9609 
October 18, 2017

Natural product-based therapy for ageing-associated diseases: A therapeutic mix encompassing Lutein, Antacin C & Hesperidin (LAH), isolated from Kale, Antrodia cinnamomea, and Oranges, respectively, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down regulation of its target gene, 19/October/2017, 1.49 am

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
October 18, 2017

Lifespan extension therapy: Rivoglitazone, an anti-hyperglycemic drug,  may increase life span via up-regulation of its target gene BubR1, 19/October/2017, 1.21 am

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]
October 18, 2017

Natural product therapy for pulmonary arterial hypertension: A therapeutic mix encompassing Curcumin and Quercetin, isolated from Turmeric and Elder berries, respectively, inhibits the development of pulmonary arterial hypertension via down regulation of  Notch3 and its target gene Hes-5, 19/October/2017, 1.00 am

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number […]
October 18, 2017

Small molecule-based GPC2 pathway blockade enhances the efficacy of Cancer immunotherapy in Neuroblastoma: A therapeutic mix encompassing Ascorbate, Delta-tocotrienol, Dehydroleucodine, & Forodesine [ADDF] inhibits the expression of GPC2, inhibits neuroblastoma proliferation, increases IFNγ signalling, increase antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 18/October/2017, 11.27 pm

Introduction:What they say: A recent study from Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA […]
October 17, 2017

Natural product-based therapy for Deafness: A therapeutic mix encompassing Salvianolic Acid B,  Cardamomin, Cholecalciferol  and DIM (SABCCAD)  increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  and improves hearing loss via up regulation of its target genes, 18/October/2017, 12.10 am

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for Deafness: A therapeutic mix encompassing Salvianolic Acid B,  Cardamomin, Cholecalciferol  and […]
October 17, 2017

Natural product-derived therapy for anxiety and depression: Artesunate, isolated from Artemisia annua L among others, decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression via down regulation of its target gene, 17/October/2017, 11.40 pm

Introduction: What they say: A study from Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; Department […]
October 17, 2017

Natural product therapy for Glaucoma:  Isorhapontigenin, isolated from Genetum and Norway spruce (Picea abies), and sitka spruce (Picea sitchensis), among others, increases Nmnat1 expression, increases NAD+ levels, improves neuroanl dysfunction, and protects against glaucoma via down regulation of its target gene, 17/October/2017, 11.34 pm

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, […]
October 17, 2017

Natural product-derived therapy for Stroke: Glabridin, isolated from Licorice/Glycyrrhiza glabra L, which is used as a food additive (Sweetener), attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via up regulation of its target genes BDNF and NAMPT, 17/October/2017, 11. 23 pm

Introduction: What they say A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; […]
October 17, 2017

Life-extension therapy: Triptolide, isolated from Thunder God Vine,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 17/October/2017, 10.52 pm

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
October 16, 2017

Xenon-based therapy for Non-alcoholic fatty liver disease (NAFLD): Xenon  promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 17/October/2017, 12.58 am

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to […]
October 16, 2017

 Natural product-derived combination therapy for blood-stage Plasmodium infection: A therapeutic mix encompassing Magnolol, Atovaquone,  and  Honokiol [MAH] decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via up regulation of its target gene, 17/October/2017, 12.50 am

Introduction: What they say A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that […]
October 16, 2017

Lifespan extension therapy:  Glabridin, isolated from Licorice/Glycyrrhiza glabra L, which is used as a food additive (Sweetener),  increases life span via up-regulation of its target gene BubR1, 17/October/2017, 12.05 am

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]

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Science is not about how to follow the conventions, but about how not to follow the conventions