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 Total no of Ideas: 10743 
September 21, 2018

A derivative of sulfamoylated Estrone comes to the rescue of anxiety and depression: 2-Ethylestrone-3-O-sulfamate (2EtEMATE) decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression, via down-regulation of its target gene, 21/September/2018, 11.00 pm

Introduction: What they say:  A study from Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; Department […]
September 21, 2018

Probiotics as anti-infective agents:  Probiotics-based adjunct therapy for viral and bacterial infections: Probiotic Lactobacillus Rhamnosus inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the antiviral Proteins IFITM3, & Interferon-stimulated gene, 21/September/2018, 10.29 pm

Introduction: What they say: A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA […]
September 21, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Mibolerone (Trade name: Cheque drops and Matenon), an anabolic-androgenic steroid, increases the expression of tumor suppressors genes, such as IGFBP3, PIAS3, p53,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 21/September/2018, 10.02 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
September 21, 2018

Natural product-based therapy for anxiety and depression: Oroxyloside (OAG), a metabolite of Oroxylin A derived from the root of Scutellaria baicalensis Georgi,  decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression, via down-regulation of its target gene, 21/September/2018, 6.20 pm

Introduction: What they say:  A study from Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; Department […]
September 21, 2018

Consuming probiotics may boost memory, learning, and cognition:  Probiotic Lactobacillus casei increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning via down-regulation of its target genes, 21/September/2018, 6.09 pm

Introduction: What they say A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center […]
September 21, 2018

A probiotic way to lengthen lifespan: Probiotic Lactobacillus Previs increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 21/September/2018, 5.45 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
September 21, 2018

Turning to Probiotic Lactobacillus acidophilus for lowering cholesterol, and triglycerides levels and for promoting weight loss: Repurposing the Probiotic Lactobacillus acidophilus  into a cholesterol-lowering agent that inhibits Non-alcoholic fatty liver disease (NAFLD): Probiotic Lactobacillus acidophilus decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD, via up-regulation of its target gene, 21/September/2018, 5.17 pm

The significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 […]
September 21, 2018

A derivative of Estrone comes to the rescue of anxiety and depression: Hydroxyestrone (16αOHE), a derivative of weak female reproductive steroid hormone Estrone, decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression, via down-regulation of its target gene, 21/September/2018, 4.56 am

Introduction: What they say:  A study from Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; Department […]
September 18, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  SMAD7, p12DOC1/CDK2AP1,  INK4a/ARF, TA-p73, TA-p63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 18/September/2018, 9.05 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
September 18, 2018

Turning to Probiotics may boost memory, learning and cognition:  Probiotic Lactobacillus Plantarum increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning via down-regulation of its target genes, 18/September/2018, 8.50 pm

Introduction: What they say A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center […]
September 18, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Andrographolide, isolated from Andrographis paniculata, increases the expression of tumor suppressors genes, such as TPM1, PDCD4, p53,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 18/September/2018, 2.19 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
September 18, 2018

A cup of probiotic a day keeps cardiac diseases at bay: Probiotic Lactobacillus casei Zhang inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 18/September/2018, 8.16 am

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac aging and function.” This study was published, in the 7 March  2013 issue of the […]

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Science is not about how to follow the conventions, but about how not to follow the conventions