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 Total no of Ideas: 11293 
March 24, 2019
Published by admin_auro at March 24, 2019
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Ribonucleic acid-based therapy for cardiomyocyte proliferation and heart regeneration: LncRNA ROR decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up-regulation of its target gene, 24/March/2019, 5.22 pm

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory […]
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March 24, 2019
Published by admin_auro at March 24, 2019
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Anti-infective Therapy: Anisomycin, a pyrrolidine antibiotic that functions a protein synthesis inhibitor,  inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 24/March/2019, 5.08 pm

Introduction: What they say: A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA […]
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March 24, 2019
Published by admin_auro at March 24, 2019
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Ribonucleic acid-based therapy for cardiac hypertrophy and fibrosis: LncRNA ROR decreases MiR-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1 and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function, via upregulation of its target gene, 24/March/2019, 4.31 pm

Introduction: What they say: A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]
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March 23, 2019
Published by admin_auro at March 23, 2019
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Mechanistic insights into how exercise may ameliorate Diabetes Mellitus: Physical exercise augments the expression of FGF19 and FGF1,  attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM, via upregulation of its target gene, 23/March/2019, 7.19 pm

Introduction: What they say  A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection […]
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March 23, 2019
Published by admin_auro at March 23, 2019
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Interleukin-based Anti-infective Therapy: IL-24  inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 23/March/2019, 7.04 pm

Introduction: What they say: A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA […]
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March 22, 2019
Published by admin_auro at March 22, 2019
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Ethyl pyruvate-based therapy for diabetes:  Ethyl pyruvate decreases DNA-PPK expression, suppresses phosphorylation of HSP90a, increases AMPK activity, augments mitochondrial biogenesis and energy metabolism, promotes weight loss and exercise endurance and alleviates TIIDM, via down-regulation of its target gene, 22/March/2019, 8.55 am

Introduction: What they say A study from the Laboratory of Obesity and Aging Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD […]
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March 22, 2019
Published by admin_auro at March 22, 2019
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A gaseous way to keep cardiac diseases at bay: Hydrogen gas-based cardiac rejuvenation therapy: Inhalation  or Subcutaneous injection of hydrogen gas suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy, via up regulation of its target gene, 22/March/2019, 8.40 am

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A gaseous way to keep cardiac diseases at bay: Hydrogen gas-based cardiac rejuvenation […]
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March 22, 2019
Published by admin_auro at March 22, 2019
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Ribonucleic acid-based therapy for Diabetes Mellitus: LncRNA LINC00319 augments the expression of FGF19 and FGF1,  attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM, via upregulation of its target gene, 22/March/2019, 8.23 am

Introduction: What they say  A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection […]
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March 22, 2019
Published by admin_auro at March 22, 2019
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Ribonucleic acid-based therapy for autoimmune diabetes (TIDM): LncRNA H19 increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 22/March/2019, 8.14 am

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and […]
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March 22, 2019
Published by admin_auro at March 22, 2019
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Ribonucleic acid-based therapy for glaucoma:  LncRNA PVT1 increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma,  via down regulation of its target gene, 22/March/2019, 8.05 am

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, […]
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March 21, 2019
Published by admin_auro at March 21, 2019
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Hydrogen gas-based therapy for attenuating pathogenesis-associated with Myocardial infarction: Subcutaneous injection or inhalation of hydrogen gas decreases IRF3, GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leukocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival, via up regulation of its target gene, 21/March/2019, 7.45 pm

Introduction: What they say: A recent study from Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA; and Cardiovascular Research Center, Massachusetts General Hospital and […]
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March 21, 2019
Published by admin_auro at March 21, 2019
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Ribonucleic acid-based therapy for autoimmune diabetes: LncRNA MEG3 increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up-regulation of its target gene, 21/March/2019, 8.49  am

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical […]
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Ideas can even be life changing.

We generate bio-medical/pharma/therapeutic/clinical ideas for the scientific community. Good Ideas are uncommon and unique. This is because everyone’s educational background is different. As a result, every one’s thinking process is different. Consequently, his/her ability to connect/understand complex biological/pathological mechanism differs.

Dr L. Boominathan Ph.D.

President & Director-cum-Chief scientist

Dr Boominathan was the first one in the world to propose a p73/p63-dependent cancer suppressor pathway (Supported by a legally valid Invention disclosure document certified by an advocate-2002/3)

Dr Boominathan’s quote on Science

Science is not about how to follow the conventions, but about how not to follow the conventions

 
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