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Total no of Ideas: 11649
Mechanistic insights into how Blue zone longevity diet protects against cardiac dysfunction: Having honey on a daily basis will protect you against cardiac dysfunction and extend lifespan:Chrysin, found in propolis and honey, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 20/February/2020, 8.10 pm
Repurposing the anti-lipidemic agent Fenofibrate into an anti-HIV agent: Fenofibrate (trade name: Fenoglide, Lipofen, Tricor and others)), an antilipidemic drug, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 20/February/2020, 9.39 am
Taurine-based regenerative therapy for curing Glaucoma: Taurine/2-Aminoethane-1-sulfonic acid increases the expression of genes that promote regeneration, promotes reprogramming of aged eye cells, increases telomerase expression, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against and reverses glaucoma, via upregulation of its target gene, 26/January/2019, 11.46 pm
Mechanistic insights into how Okinawan longevity diet protects against cardiac dysfunction: Having turmeric tea on a daily basis will protect you against cardiac dysfunction and extend lifespan: Curcumin (Diferuloylmethane), found in turmeric, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 20/January/2020, 11.54 pm
Lifespan extension therapy comes of age: Metfomin aids in Lifespan extension: Metformin, the widely prescribed drug in the treatment of type II diabetes, activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, increases adult stem cell proliferation, alleviates ageing feature and extends lifespan, via upregulation of its target genes ATG5 (Autophagy-related 5) and telomerase, 18/January/2020, 11.59 pm
Sauna/Waon based regenerative cardiovascular therapy: Molecular mechanistic insight into how Sauna/Waon therapy protects against and promotes functional recovery after Myocardial Infarction: Sauna(heat/thermal)/Waon therapy inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte proliferation, regeneration and survival after myocardial infarction, via up-regulation of its target gene, 17/January/2019, 10.45 pm
Probiotic-based Chemotherapy (PCT) targeting cancer stem cells and immune-inhibitory receptors in metastatic breast cancer and in other advanced metastatic cancers: A pharmaceutical mixture encompassing Acarbose [trade name: Glucobay, Precose, Prandase]and probiotic Lactobacillus rhamnosus (ALR) increases the expression of tumor suppressor genes, such as TPM1(Tropomycin1), TIMP3 (TIMP Metallopeptidase Inhibitor 3), p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance and prolongs survival, and stalls metastatic breast cancer progression, via up-regulation of its target gene, 16/January/2019, 12.11 am
Lutin/Zeaxanthin-based regenerative therapy for curing Glaucoma: A pharmaceutical mixture encompassing Lutin & Zeaxanthin increases the expression of genes that promote regeneration, promotes reprogramming of aged eye cells, increases telomerase expression, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against and reverses glaucoma, via up-regulation of its target gene, 9/January/2020, 5.51 am
Mechanistic insights into how Okinawan longevity diet reduces blood pressure: Consuming ample amounts of Sweet potatoes will reduce blood pressure and extend lifespan: Sweet potato-derived compounds function as longevity promoters: ß-carotene, derived from sweet potatoes, decreases blood pressure and blood sugar levels, attenuates cardiac dysfunction, increases regeneration of tissues, and prolongs life span, via down regulation of angiotensin II type I receptor (AT1R), 5/January/2019, 2.51 pm
Little RNA can protect against cardiac dysfunction: LncRNA NEAT1-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: LncRNA NEAT1 (Nuclear Enriched Abundant Transcript 1 (NEAT1) increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes, via up-regulation of its target gene, 31/December/2019, 11.41 pm
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Ideas can even be life changing.
We generate bio-medical/pharma/therapeutic/clinical ideas for the scientific community. Good Ideas are uncommon and unique. This is because everyone’s educational background is different. As a result, every one’s thinking process is different. Consequently, his/her ability to connect/understand complex biological/pathological mechanism differs.