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 Total no of Ideas: 10996 
December 13, 2018
Published by admin_auro at December 13, 2018
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Molecular Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Valproic acid (brand names: Convulex, depakote, epilim, stavzor and others), a drug used to treat seizures/epilepsy, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 13/December/2018, 11.41 pm

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
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December 13, 2018
Published by admin_auro at December 13, 2018
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Probiotic-based therapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing  probiotics Clostridium butyricum MIYAIRI 588 (CBM588) and Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as TPM1, CCM3/KRIT1, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 13/December/2018, `11.27 pm

  What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that: Probiotic-based therapy targeting cancer stem […]
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December 13, 2018
Published by admin_auro at December 13, 2018
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AP-1-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: AP-1 (Activator protein-1) increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 13/December/2018, 11.16 pm

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
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December 13, 2018
Published by admin_auro at December 13, 2018
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Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing   SAHA (Suberoylanilide Hydroxamic Acid) and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as TPM1, CCM3/KRIT1, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 13/December/2018, `11.01 pm

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that: Probiotic-based chemotherapy targeting cancer stem cells […]
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December 12, 2018
Published by admin_auro at December 12, 2018
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Hematopoietin-based therapy for body weight control, energy homeostasis and TIIDM: Erythropoietin (EPO)/Hematopoietin, a glycoprotein cytokine that promotes erythropoiesis, inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 12/December/2018, 11.00 am

Introduction: What they say  A study from Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, United States shows that “Dnmt3a is an epigenetic mediator […]
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December 12, 2018
Published by admin_auro at December 12, 2018
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Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing   MiRNA-129 and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as TPM1, CCM3/KRIT1, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 12/December/2018, `10.47 am

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that: Probiotic-based chemotherapy targeting cancer stem cells […]
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December 12, 2018
Published by admin_auro at December 12, 2018
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A probiotic way to ameliorate Diabetes Mellitus: Probiotic VSL#3 augments the expression of FGF19 and FGF1,  attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM, via upregulation of its target gene, 12/December/2018, 7.06 am

Introduction: What they say  A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection […]
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December 12, 2018
Published by admin_auro at December 12, 2018
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XBP1-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: XBP1, a regulator of the immune system, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 12/December/2018, 6.47 am

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
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December 12, 2018
Published by admin_auro at December 12, 2018
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Hematopoietin functions as a longevity promoter: Erythropoietin (EPO)/Hematopoietin, a glycoprotein cytokine that promotes erythropoiesis, may  increase insulin sensitivity, slow down cardiac aging, and increase lifespan, via up-regulation of BubR1 and others genes, 12/Decemeber/2018, 6.35 am

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, USA; […]
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December 12, 2018
Published by admin_auro at December 12, 2018
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A probiotic way to stay free of autoimmune diabetes: Probiotic VSL#C increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up-regulation of its target gene, 12/December/2018, 6.19 am

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical […]
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December 11, 2018
Published by admin_auro at December 11, 2018
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Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing   lncRNA Hand2-AS1 and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as KIBRA, p57Kip2, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 9/December/2018, `11.36pm

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that:  Probiotic-based chemotherapy targeting cancer stem cells […]
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December 11, 2018
Published by admin_auro at December 11, 2018
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Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing Pimozide, an antipsychotic drug, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as PDCD4, CADM1, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 11/December/2018, 11.29 pm

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that: Probiotic-based chemotherapy targeting cancer stem cells […]
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Ideas can even be life changing.

We generate bio-medical/pharma/therapeutic/clinical ideas for the scientific community. Good Ideas are uncommon and unique. This is because everyone’s educational background is different. As a result, every one’s thinking process is different. Consequently, his/her ability to connect/understand complex biological/pathological mechanism differs.

Dr L. Boominathan Ph.D.

President & Director-cum-Chief scientist

Dr Boominathan was the first one in the world to propose a p73/p63-dependent cancer suppressor pathway (Supported by a legally valid Invention disclosure document certified by an advocate-2002/3)

Dr Boominathan’s quote on Science

Science is not about how to follow the conventions, but about how not to follow the conventions

 
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