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May 22, 2018

A salty way to keep the cardiac diseases at bay-hard to believe though(!): Hypertonic saline-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients:  Hypertonic saline (10%) increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene, 23/May/2018, 12.58 am

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
May 22, 2018

A fibrous way to strengthen your heart and extend lifespan: β-glucan-based therapy for cardiomyopathy: β-glucan, found abundantly in oats and barley, may  suppress tumor suppressor INK4a/p16 expression, inhibit dilated cardiomyopathy and extend life span, via up regulation of its target gene, 23/May/2018, 12.37 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  A fibrous way to strengthen your heart and extend lifespan: β-glucan-based therapy for cardiomyopathy: β-glucan, found […]
May 22, 2018

A handful of fiber-rich Oats and barley a day keeps the cardiac diseases at bay: Fiber-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients:  β-glucan, found abundantly in Oats and barely, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene, 23/May/2018, 12.10 am

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
May 22, 2018

A salty way to say no to pain: Hypertonic saline-based Pain therapy: Hypertonic saline (10%) increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 22/May/2018, 11.48 pm

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
May 22, 2018

A sweet way to say no to myocardial diseases: Sugar-based therapy for cardiac repair and myocardial infarction: Raffinose, a trisaccharide isolated from cotton seed flour, increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 22/May/2018, 11.35 pm

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, […]
May 22, 2018

A fibrous way to say no to Cardiomyopathy: β-glucan, found abundantly in oats and barley, decreases the expression of Sox6, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 22/May/2018, 11.03 pm

Introduction: What they say   A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart […]
May 22, 2018

A salty way to say no to cardiac diseases-hard to believe though (!): Hypertonic saline-based therapy for attenuating pathogenesis-associated with Myocardial infarction: Hypertonic saline (10%) decreases IRF3 (Interferon regulatory transcription factor-3), GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival, via up regulation of its target gene, 22/May/2018, 3.45 pm

Introduction: What they say: A recent study from Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA; and Cardiovascular Research Center, Massachusetts General Hospital and […]
May 20, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Hydrogen-rich saline increases the expression of tumor suppressors genes, such as  p53, TA-p73 and TA-p63, TIMP3, and CCM3/KRIT1, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 20/May/2017, 4.56 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
May 20, 2018

Molecular therapy for Deafness: A therapeutic mix encompassing Lactulose, Cholecalciferol, Ajoene and DIM (LCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 20/May/2018, 4.43 pm

  What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:   Molecular therapy for Deafness: A therapeutic mix encompassing Lactulose, Cholecalciferol, Ajoene and DIM (LCAD) increases the […]
May 20, 2018

Molecular therapy for cardiomyocyte proliferation and heart regeneration: A pharmaceutical mixture encompassing   3,3′-Diindolylmethane (DIM) Sodium nitrite(NaNO2), and  Sodium Sulfide (DIMSNSS) decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up regulation of its target gene, 20/May/2018, 4.29 pm

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory […]
May 20, 2018

A sweet way to strengthen your heart-too good to be true(!): Oligofructose-based therapy for Cardiomyopathy: Agavins (Oligofructose), a new natural sugar isolated from agavi, may  suppress tumor suppressor INK4a/p16 expression, and inhibit dilated cardiomyopathy, via up regulation of its target gene, 20/May/2018, 3.36 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  A sweet way to strengthen your heart-too good to be true(!): Oligofructose-based therapy for Cardiomyopathy: Agavins […]
May 18, 2018

A glycolipid-based therapy for glucose homeostasis and TIIDM: α-Galactosylceramide (α-gal-cer), a synthetic glycolipid, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 18/May/2018, 2.03 pm

Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, […]

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Dr Boominathan’s quote on Science

Science is not about how to follow the conventions, but about how not to follow the conventions