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May 26, 2017

Natural product-derived therapy for Metastatic cancers: Celastrol, isolated from Thunder God Vine, decreases the expression of metastasis promoters, such as Fibronectin-I, RhoE and Zeb1/2, increases the expression of metastasis suppressor E-Cadherin, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 26/May/2017, 11.10 pm

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
May 26, 2017

Natural product-derived therapy for Metastatic cancers: Solasodine, found in Solanum melongena, increases the expression of metastasis suppressor Fas Ligand and the DNA repair protein hMSH, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 26/May/2017, 11.10 pm

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
May 26, 2017

Natural product-derived therapy for Metastatic cancers: Baurenol, found in Suregada Angustifolia, decreases the expression of metastasis promoters ZBTB2 and PPM1F, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 26/May/2017, 11.08 pm

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
May 26, 2017

Natural product-derived therapy for Stroke: Hesperidin, isolated from Peppermint and blood orange, training attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF., 26/May/2017, 11.07 pm

Introduction: What they say A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; […]
May 26, 2017

Natural product-derived therapy for Stroke: 18β-Glycyrrhetinic acid (18β-GA), isolated from Licorice, augments regenerative neurogenesis after Ischemic Stroke and ameliorates stroke damage and neurological deficits via up regulation of its target gene NAMPT, 26/May/2017,11.05 pm

Introduction: What they say A recent study from From the Department of Pharmacology, Second Military Medical University, Shanghai, China; Department of Science and Education, Shandong Provincial Hospital […]
May 26, 2017

Natural product-derived therapy for Human cancers: Myrtenal, one of the main components of Cardamom, increases the expression of mitochondrial protein LACTB, decreases levels of mitochondrial phosphatidylserine decarboxylase, alters mitochondrial lipid metabolism, and promotes differentiation of breast cancer cells via up-regulation of its target gene, 26/May/2017, 11.04 pm

Introduction: What they say: A study from the Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts, USA, Department of Biology, Massachusetts Institute of Technology, […]
May 26, 2017

Natural mineral rich water therapy for Metabolic diseases: Natural mineral rich water increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene., 26/May/2017, 11.03 pm

Introduction: What they say A study from the Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland shows that “MicroRNAs 103 and 107 regulate insulin sensitivity.” […]
May 26, 2017

Music therapy for Lifespan extension: Music therapy prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 26/May/2017, 11.02 pm

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown […]
May 26, 2017

Natural product therapy for glucose homeostasis and TIIDM: Nectandrin B, isolated from Nutmug, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 26/May/2017, 11.01 pm

Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, […]
May 26, 2017

Music therapy for TIIDM and Metabolic defects: Music therapy increases Sirtuin-4 expression, augments insulin secretion, reduces metabolic stress, improves glucose uptake, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 26/May/2017, 11.00 pm

Introduction: What they say A study from the “Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC […]
May 25, 2017

Natural product-based cardiac regeneration therapy: Fisetin, isolated from Strawberry, suppresses tumor suppressor INK4a/p16 expression, inhibits dilated cardiomyopathy and heart failure and extends life span via up regulation of its target gene, 25/May/2017, 11.56 pm

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based cardiac regeneration therapy: Fisetin, isolated […]
May 25, 2017

Amino acid based Lifespan extension therapy: L-Leucine, the branched chain essential amino acid, decreases the expression of Myostatin, inhibits aging-related decline in muscle function and enhances the longevity of mammals via up regulation of its target gene, 25/May/2016, 11.15 pm

Introduction:  A study from the Department of Orthopaedic Surgery, University of Michigan Medical School, USA; and Department of Molecular & Integrative Physiology, University of Michigan Medical School, […]

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Dr Boominathan’s quote on Science

Science is not about how to follow the conventions, but about how not to follow the conventions