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 Total no of Ideas: 11465 
May 19, 2019

Natural sugar-based therapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing a pharmacological formulation encompassing Xylobiose (a disaccharide of xylose, with a  a beta-1,4-bond), and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as  SOCS6, APAF1, E-cadherin, p53, and TA-p73/p63, stalls cell cycle progression, inhibits immune-inhibitory receptors/molecules, suppresses cancer stem cell proliferation, inhibits migration, invasion and metastasis of cancer cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 20/May/2019, 12.47 am

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that:  Natural sugar-based therapy targeting cancer stem […]
May 19, 2019

Atrasentan-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Atrasentan, an endothelin receptor antagonist selective for subtype A (ETA) used to treat cancer, pulmonary hypertension, diabetic kidney diseases and others, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 20/May/2019, 12.39 am

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
May 18, 2019

Essential oil-derived compound functions as an anti-HIV agent: Carvacrol increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 18/May/2017, 11.46 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Essential oil-derived compound functions as an anti-HIV agent: Carvacrol increases Heme oxygenase 2 (HO-2) expression, […]
May 18, 2019

Natural product-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Carvacrol increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via upregulation of its target gene, 18/May/2019, 11.36 pm

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex […]
May 17, 2019

Ribonucleic acid-based therapy for enhancing memory and cognition: LncRNA CCDC26  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 17/May/2019, 11.55 pm

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center […]
May 17, 2019

Ribonucleic acid-based therapy for enhancing memory and cognition: LncRNA SNHG14  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 17/May/2019, 11.50 pm

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center […]
May 17, 2019

Excess consumption of coffee during pregnancy increases the chances of spontaneous abortion, stillbirth & prenatal mortality: Caffeine increases DNA damage responses, suppresses telomerase expression, attenuates telomere shortening, inhibits cardiomyocyte survival, promotes cardiomyocytes apoptosis, and promotes myocardial dysfunction, via down-regulation of PNUTS, 17/May/2019, 11.22 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of […]
May 17, 2019

Blood pressure drug Verapamil comes to the rescue of blood sugar disease: Verapamil (brand name: Calan, Isoptin and others), a calcium channel blocker that aids in the treatment of high blood pressure, angina pectoris, supraventricular tachyarrhythmias and others,   inhibitor used in the treatment of hyperglycemia,  increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 17/May/2019, 10.40 pm

 Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]
May 17, 2019

Molecular therapy may attenuate pathogenesis-associated with Myocardial infarction: Canagliflozin  (Brand name: Invokana, Sulisent, Prominad, others), an anti-hyperglycemic medication used to treat type II diabetes, decreases GM-CSF (Granulocyte-macrophage colony-stimulating factor) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits left ventricular rupture, and promotes heart healing via up regulation of its target gene, 17/May/2019, 10.25 pm

Introduction: What they say: A recent study from Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; and Center for Systems […]
May 16, 2019

Natural product-based therapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing Carvacrol, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as  TPM1, CADM1/2,  E-cadherin, p53, and TA-p73/p63, stalls cell cycle progression, inhibits immune-inhibitory receptors/molecules, suppresses cancer stem cell proliferation, inhibits migration, invasion and metastasis of cancer cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 16/May/2019, 10.52 pm

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that:  Natural product-based therapy targeting cancer stem […]
May 16, 2019

Natural sugar-based therapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing a pharmacological formulation encompassing Xylobiose (a disaccharide of xylose, with a  a beta-1,4-bond), and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as  p57Kip2, p12DOC1, E-cadherin, p53, and TA-p73/p63, stalls cell cycle progression, inhibits immune-inhibitory receptors/molecules, suppresses cancer stem cell proliferation, inhibits migration, invasion and metastasis of cancer cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 16/May/2019, 10.39 pm

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that:  Natural sugar-based therapy targeting cancer […]
May 16, 2019

Carvacrol as a broad-spectrum anti-infective agent:  Carvacrol, one of the main components of Origanum vulgare, Thyme, Lipidium & Lavandula multifida,  inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 16/May/2019,  10.27 pm

Introduction: What they say: A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA […]

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Science is not about how to follow the conventions, but about how not to follow the conventions