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 Total no of Ideas: 10913 
November 17, 2018

Molecular therapy for blood sugar disease: MANF (Mesencephalic astrocyte-derived neurotrophic factor) increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 17/November/2018, 8.49am

Introduction: What they say A study from the Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, the University of Alabama at […]
November 17, 2018

Probiotic-based therapy for diabetic retinopathy: Probiotic Bifidobacterium lactis HY8101 inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down-regulation of its target gene, 17/November/2018, 8.35 am

Introduction: What they say A study from the Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; and German Centre for […]
November 17, 2018

Curry’s main ingredient/ coloring agent Curcumin may extend the lifespan of humans: Curcumin-based Lifespan extension therapy: Curcumin, found in turmeric,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 17/November/2018, 8.16 am

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
November 16, 2018

Probiotic-based therapy for pulmonary arterial hypertension (PAH): Bifidobacterium lactis LKM512-containing yogurt inhibits the development of pulmonary arterial hypertension via down-regulation of its target gene Notch3, 17/November/2018, 12.11 am

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November  2009 issue of the journal “Nature Medicine”[the number […]
November 16, 2018

Valproic acid-based therapy for blood sugar disease: Valproic acid  increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 16/October/2018, 11.57 pm

Introduction: What they say A study from the Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, the University of Alabama at […]
November 16, 2018

Lighting your way to lower cholesterol, and triglycerides levels: Intense blue light exposure decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via up-regulation of its target gene, 16/November/2018, 11.48 pm

The significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 […]
November 16, 2018

Lengthening the lifespan of mighty humans with a tiny Probiotic Lactobacillus reuteri GMNL-263: Probiotic Lactobacillus reuteri GMNL-263 may  increase insulin sensitivity, slow down cardiac aging, and increase lifespan, via up-regulation of BubR1 and others longevity-promoting genes, 16/November/2018, 11.34 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, USA; […]
November 15, 2018

Probiotic-based therapy for Squamous cell carcinoma of head and neck (HNSCC): Probiotic Lactobacillus Rhamnosus inhibits BMI1 and AP-1 expression, overcomes chemotherapeutic resistance, promotes chemosensitivity, suppresses cancer stem cells in HNSCC, and inhibits lymph node metastasis, via down-regulation of its target genes, 16/November/2018, 12.03 am

Introduction: What they say: A study from the Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, Jonsson Comprehensive Cancer Center and Broad Stem Cell Research […]
November 15, 2018

Molecular therapy for Myocardial Infarction: Empagliflozin (trade name Jardiance), used in the treatment of TIIDM, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 15/November/2018, 11.48 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of […]
November 15, 2018

Probiotic-based therapy for prostate cancer bone metastasis: Probiotic Lactobacillus Rhamnosus inhibits the expression of Monoamine oxidase A (MAOA), inhibits Shh-IL6-RANKL signaling network, suppresses tumor-stromal interactions, reduces prostate cancer metastasis and prolongs survival via up regulation of its target gene, 15/November/2017, 11.32 pm

Introduction: What they say: A study from the Uro-Oncology Research Program, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA shows that “MAOA-Dependent Activation of Shh-IL6-RANKL Signaling Network […]
November 15, 2018

Molecular therapy for cardiac dysfunction: Empagliflozin (trade name: Jardiance), used in the treatment of TIIDM, decreases Mir-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function, via upregulation of its target gene, 15/November/2018, 11.22 pm

Introduction: What they say:   A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]
November 15, 2018

Probiotic-based therapy for pulmonary arterial hypertension (PAH): Probiotic Lactobacillus Rhamnosus inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 15/November/2018, 10.48 pm

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November  2009 issue of the journal “Nature Medicine”[the number […]

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