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Total no of Ideas: 9501
Natural product-derived CDK4/6 pathway blockade enhances the efficacy of Cancer immunotherapy: A pharmacological mixture encompassing Shikonin, Amitriptyline, Rosustatin,Cholecalciferol, Hypericin, Nimpolide, PEITC, Linalool and Salinomycin (SARCHNPLS) inhibits the expression of cell cycle protein CDK4/CDK6, increases levels of T-III IFNs, inhibits the proliferation of Treg cells, decreases DNMT1 expression, inhibits the expression of a number of immune evasion molecules, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target genes, 23/September/2017, 11.51 pm
Natural product-derived therapy for inflammation and arthritis: Berberine, isolated from Berberis Vulgaris, increases IL-9 levels, increases proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up regualtion of its target genes, 23/September/2017, 11.11 pm
Natural product-derived therapy for Stroke: Catalpol, isolated from Catalpa, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via up regulation of its target genes BDNF and NAMPT, 23/June/2017, 11.01 pm
Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Withaferin A (WA), Diindolylmethane (3,3′-DIM, DIM) and Vitamin-D activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 23/September/2017, 2.06 am
Antiviral therapy for Hepatitis-B virus: Suramin increases the expression of Setd2, methylates STAT1, activates STAT1, promotes trimethylation of IFN-stimulated gene-15, and restricts Hepatitis-B virus (HBV) production and pathogenesis via up regulation of its target gene, 23/September/2017, 1.56 pm
Exercise mementics therapy for Metabolic disease: a therapeutic mix encompassing Puerarin and Farryrol increases PPARδ and Foxo1 levels, inhibits glucose catabolism, preserves glucose levels, stimulates FA catabolism, delays the onset of hypoglycemia and boosts endurance exercise via down regulation of its target gene, 23/September/2017, 1.46 am
Natural product-based Anti-ageing and Life extension therapy: A pharmaceutical mixture encompassing Naringenin, Astaxanthin, alpha-Tocopherol, Ergothioneine (NATE) increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan via down regulation of its target gene, 21/September/2017, 11.57 pm
Antiviral therapy for Hepatitis-B virus: Sodium Selenite increases the expression of Setd2, methylates STAT1, activates STAT1, promotes trimethylation of IFN-stimulated gene-15, and restricts Hepatitis-B virus (HBV) production and pathogenesis via up regulation of its target gene, 21/September/2017, 10.41 pm
PD-1 pathway activation for Pain therapy: Fluoxetine, the widely used drug in the treatment of depression, mood disorders among others, increases the expression of PD-L1, attenuates acutes and chronic pain, suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gen, 21/September/2017, 10.30 pm
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Ideas can even be life changing.
We generate bio-medical/pharma/therapeutic/clinical ideas for the scientific community. Good Ideas are uncommon and unique. This is because everyone’s educational background is different. As a result, every one’s thinking process is different. Consequently, his/her ability to connect/understand complex biological/pathological mechanism differs.