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 Total no of Ideas: 11563 
July 19, 2019

Thymol-based regenerative therapy for improving cognitive deficits in the aged individuals: Thymol, isolated from Trachyspermum Ammi/Ajwain seeds and oil,  decreases vascular cell adhesion molecule 1 (VCAM 1), inhibits microglia activity, increases hippocampal neural precursor activity, ameliorates cognition, & attenuates age-related neurodegeneration, through up regulation of its target genes, 19/July/2019, 9.29 pm

Introduction: What they say A study from the Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA, VA Palo Alto Health […]
July 18, 2019

Natural product-derived Analgesics:  Mechanistic insights into how natural product-derived Manassantin B  functions as a pain medication: Manassantin B, isolated from Saururus chinensis (also known as Asian lizard’s tail), increases the expression of PD-L1, TRPV1, and CGPR, decreases the expression of Cox-2, attenuates acutes and chronic pain, headache, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 17/July/2019, 10.23 am

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
July 17, 2019

Natural product-based Lifespan extension therapy:  Diosgenin, derived from Dioscorea,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 17/July/2019, 11.10 pm

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
July 17, 2019

Where eating the peel will protect you against viral diseases than the pulp (fruit): Citrus peel-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Hesperidin, Tangeretin & Nobiletin (HTN), isolated from citrus flavonoid purity mixture or citrus peels, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via upregulation of its target gene, 17/July/2019, 10.40 pm

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex […]
July 17, 2019

Probiotics as Longevity-promoters: The tiny probiotic may increase the lifespan of mighty humans: Probiotic-based therapy for aging-associated diseases and Lifespan extension: Probiotic Bifidobacterium animalis subsp.lactis LKM512 inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 17/July/2019, 10.10 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
July 17, 2019

Probiotics as Analgesics: Probiotic bifidobacterium animalis subsp. lactus LKM512  functions as a pain reliever: Mechanistic insights into how Probiotic bifidobacterium animalis subsp. lactus LKM512  functions as a pain medication: Probiotic bifidobacterium animalis subsp. lactus LKM512  increases the expression of PD-L1, TRPV1, and CGPR, decreases the expression of Cox-2, attenuates acutes and chronic pain, headache, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 17/July/2019, 11.51 am

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
July 15, 2019

Surgery to mitigate complications of diabetes and obesity comes of age: Mechanistic insights into how Roux-en-Y gastric bypass (RYGB) surgery can save you from blood sugar disease (Diabetes Mellitus): Roux-en-Y gastric bypass (RYGB), one of the bariatric surgical procedure performed for weight loss,  augments the expression of FGF19 and FGF1,  attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM, via upregulation of its target gene, 15/July/2019, 7.41 am

Introduction: What they say  A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection […]
July 15, 2019

Small molecule-based Lifespan extension comes of age-β-guanidinopropionic acid (β-GPA) aids in Lifespan extension: β-guanidinopropionic acid (β-GPA) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, increases adult stem cell proliferation, alleviates ageing feature and extends lifespan, via upregulation of its target genes ATG5 (Autophagy-related 5) and telomerase, 15/July/2019, 10. 6.31 am

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was […]
July 14, 2019

Solving a long standing puzzle as to how Astragalus membranaceus functions as a pain reliever: Mechanistic insights into how Astragalus membranaceus-derived compound Astragaloside  functions as a pain medication: Astragaloside, derived from Astragalus membranaceus or its oil,  increases the expression of PD-L1, TRPV1, and CGPR, decreases the expression of Cox-2, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 12/July/2019, 11.39 pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
July 14, 2019

Surgery for Lifespan extension comes of age-Bariatric surgery aids in Lifespan extension: Mechanistic insights into how Bariatric surgery promotes longevity in obese patients and in aged patients: Bariatric surgery activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, increases adult stem cell proliferation, alleviates ageing feature and extends lifespan via upregulation of its target genes ATG5 (Autophagy-related 5) and telomerase, 14/July/2019, 10.58 pm

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was […]
July 12, 2019

Little RNA can protect your heart from Myocardial diseases: LncRNA MIRT2 (Myocardial infarction-associated transcript 2 (Mirt2)-based therapy for Cardiac repair and myocardial infarction: LncRNA  Mirt2  increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up-regulation of its target gene, 12/July/2019, 11.47 pm

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, […]
July 12, 2019

Solving a century-old puzzle as to how Turmeric functions as a pain reliever: Mechanistic insights into how Turmeric-derived compound Curcumin functions as a pain medication: Curcumin, derived from turmeric or its oil,  increases the expression of PD-L1, decreases the expression of Cox-2, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 12/July/2019, 11.27 pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]

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