Genome Discovery

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 Total no of Ideas: 9734 
November 18, 2017

 Molecular therapy for Glaucoma:  Rosiglitaone, an  insulin sensitizer, increases Nmnat1 expression, increases NAD+ levels, improves neuroanl dysfunction, and protects against glaucoma via down regulation of its target gene, 18/October/2017, 11.25 pm

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, […]
November 18, 2017

Lifespan extension therapy:Tesaglitazar (AZ242), an insulin sensitizer,  may increase life span via up-regulation of its target gene BubR1, 19/October/2017, 11.14 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]
November 18, 2017

Natural product-derived therapy for attenuating associated with Myocardial infarction: Formononetin, found  in Trifolium pratense and Maackia amurensis, decreases GM-CSF (Granulocyte-macrophage colony-stimulating factor) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits left ventricular rupture, and promotes heart healing via up regulation of its target gene, 18/November/2017, 8.19 am

Introduction: What they say: A recent study from Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; and Center for Systems […]
November 18, 2017

Combinatorial therapy for Cardiac rejuvenation, diabetic-associated complications and Hypertension: A therapeutic mix encompassing  Aspirin and Fidarestat (AF) suppresses tumor suppressor INK4a/p16 expression, promotes cardiac repair, delays cardiac ageing and senescence, attenuates diabetic nephropathy, insulin resistance and hypertension and extends life span via up regulation of its target gene, 18/November/2017, 8.03 am

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Combinatorial therapy for Cardiac rejuvenation, diabetic-associated complications and Hypertension: A therapeutic mix encompassing  Aspirin and […]
November 17, 2017

Combinatorial Antiviral Therapy (CAT): A pharmaceutical mixture encompassing Mycophenolic acid (MPA) & Imipiramine (IMP) inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, SARS. Influenza H1NI1,  respiratory syncytial ,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 17/November/2017,  7.20 pm

Introduction: What they say:  A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA […]
November 17, 2017

Natural product-derived therapy for anxiety and depression: Valerian decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression via down regulation of its target gene, 17/November/2017, 7.50 am

Introduction: What they say: A study from Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; Department […]
November 17, 2017

Lifespan extension therapy:  Indomethacin, a Nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of pain, inflammation, stiffness and swelling,  increases life span via up-regulation of its target gene BubR1, 17/November/2017, 6.25 am

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]
November 17, 2017

Molecular therapy for Stroke:  Butylphthalide (3-n-butylphthalide or NBP), found in celery oil, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via up regulation of its target genes BDNF and NAMPT, 17/November/2017, 5.54 am

Introduction: What they say A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; […]
November 17, 2017

Natural product-based therapy for Deafness: A therapeutic mix encompassing Safranal, Cholecalciferol  and DIM (SCAD)  increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  and improves hearing loss via up regulation of its target genes, 17/November/2017, 5.41 am

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for Deafness: A therapeutic mix encompassing Safranal, Cholecalciferol  and DIM (SCAD)  increases the expression of […]
November 16, 2017

Natural product-derived therapy for anxiety and depression: Sedanolide, isolated from Celery/Apium graveolens Var. dulce, decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression via down regulation of its target gene, 16/November/2017, 11.47 am

Introduction: What they say: A study from Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; Department […]
November 16, 2017

Molecular therapy for Diabetic nephropathy (DN):  Epalrestat, an aldose reductase inhibitor used in the treatment of Diabetes Nephropathy, increases Pyruvate kinase M2 (PKM2) expression, decreases toxic glucose metabolites, mitochondrial dysfunction and apoptosis, augments glycolytic flux and PGC-1α levels, improves metabolic abnormalities, albuminuria, glomerular pathology, and renal dysfunction and alleviates diabetic nephropathy via down regulation of its target gene, 16/November/2017, 10.35 am

Introduction: What they say A study from the Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA shows that “Pyruvate kinase M2 activation may protect against the […]
November 16, 2017

Lifespan extension therapy: 15-deoxy-Delta,12,14-prostaglandin J2 (15d-PGJ2) may increase life span via up-regulation of its target gene BubR1, 16/November/2017, 10.10 am

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]

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Dr Boominathan’s quote on Science

Science is not about how to follow the conventions, but about how not to follow the conventions