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Total no of Ideas: 9734
Natural product-derived therapy for attenuating associated with Myocardial infarction: Formononetin, found in Trifolium pratense and Maackia amurensis, decreases GM-CSF (Granulocyte-macrophage colony-stimulating factor) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits left ventricular rupture, and promotes heart healing via up regulation of its target gene, 18/November/2017, 8.19 am
Combinatorial therapy for Cardiac rejuvenation, diabetic-associated complications and Hypertension: A therapeutic mix encompassing Aspirin and Fidarestat (AF) suppresses tumor suppressor INK4a/p16 expression, promotes cardiac repair, delays cardiac ageing and senescence, attenuates diabetic nephropathy, insulin resistance and hypertension and extends life span via up regulation of its target gene, 18/November/2017, 8.03 am
Combinatorial Antiviral Therapy (CAT): A pharmaceutical mixture encompassing Mycophenolic acid (MPA) & Imipiramine (IMP) inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, SARS. Influenza H1NI1, respiratory syncytial , Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 17/November/2017, 7.20 pm
Molecular therapy for Stroke: Butylphthalide (3-n-butylphthalide or NBP), found in celery oil, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via up regulation of its target genes BDNF and NAMPT, 17/November/2017, 5.54 am
Natural product-based therapy for Deafness: A therapeutic mix encompassing Safranal, Cholecalciferol and DIM (SCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration, and improves hearing loss via up regulation of its target genes, 17/November/2017, 5.41 am
Natural product-derived therapy for anxiety and depression: Sedanolide, isolated from Celery/Apium graveolens Var. dulce, decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression via down regulation of its target gene, 16/November/2017, 11.47 am
Molecular therapy for Diabetic nephropathy (DN): Epalrestat, an aldose reductase inhibitor used in the treatment of Diabetes Nephropathy, increases Pyruvate kinase M2 (PKM2) expression, decreases toxic glucose metabolites, mitochondrial dysfunction and apoptosis, augments glycolytic flux and PGC-1α levels, improves metabolic abnormalities, albuminuria, glomerular pathology, and renal dysfunction and alleviates diabetic nephropathy via down regulation of its target gene, 16/November/2017, 10.35 am
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Ideas can even be life changing.
We generate bio-medical/pharma/therapeutic/clinical ideas for the scientific community. Good Ideas are uncommon and unique. This is because everyone’s educational background is different. As a result, every one’s thinking process is different. Consequently, his/her ability to connect/understand complex biological/pathological mechanism differs.