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April 22, 2018

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Dexoycholic acid increases the expression of tumor suppressors genes, such as TA-p73/p63, TPM1, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 22/April/2017, 11.29 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
April 22, 2018

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Amitriptyline (trade name: Elavil), a medication used to treat major depressive disorder, anxiety disorder, and bipolar disorder, increases the expression of tumor suppressors genes, such as TIMP3, CCM3/KRIT1, TA-p73/p63, TPM1, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 22/April/2017, 11.24 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
April 22, 2018

Molecular therapy for Deafness: A therapeutic mix encompassing Clofibrate, Cholecalciferol, Ajoene and DIM (CCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 22/April/2018, 11.12 pm

  What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Deafness: A therapeutic mix encompassing Clofibrate, Cholecalciferol, Ajoene and DIM (CCAD) increases the […]
April 22, 2018

Molecular therapy for blood-stage Plasmodium infection: Oleic acid, isolated from olive oil, avocado and others,  decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via up regulation of its target gene, 22/April/2018, 11.03 pm

Introduction: What they say A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that […]
April 21, 2018

Mechanistic insights into how  Brimonidine functions as an anti-glaucoma agent: Brimonidine (trade name: Alphagan and Alphagan-P), used in the treatment of open-angle glaucoma and ocular hypertension,  increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma,  via down regulation of its target gene, 21/April/2018,  8.54 am

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, […]
April 21, 2018

Natural product-derived therapy for cardiomyocyte proliferation and heart regeneration: A pharmaceutical mixture encompassing  Panaxynol, Triptolide and Sulforaphane (PTS) decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up regulation of its target gene, 21/April/2018, 8.10am

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory […]
April 21, 2018

Turning on the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, increases the expression of tumor suppressors genes, such as GRHL3, long ncRNA Gas5, BigH3, TIPE2, PTEN, PDCD4, INK4a, BTG2, TA-p73/p63, TPM1, TIMP3, CCM1/KRIT1 and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 21/April/2017, 8.00 am

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
April 21, 2018

Natural product-derived therapy for Malaria: Nordihydroguaiaretic acid (NDGA) increases Ferroportin expression, decreases intracellular iron accumulation, inhibits cellular damage, prevents hemolysis, and inhibits malaria infection, via upregulation of its target gene, 21/April/2018, 7.40 am

Introduction: What they say: A study from the Section on Human Iron Metabolism, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes […]
April 21, 2018

A sweet way to protect your heart from cardiac diseases and cardiac ageing: Phyllodulcin, a natural sweetener  400-800 times sweeter than sugar, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up regulation of PNUTS, 21/April/2018, 7.33 am

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of […]
April 21, 2018

Bonding your way to lead a pain-free life: Oxytocin-based activation of the PD-1 pathway for Pain therapy: Oxytocin (also known as compassion/goodness/bonding hormone), a peptide hormone and neuropeptide known to play a role in empathy, generosity, childbirth and so on, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 21/April/2018, 7.07 am

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
April 20, 2018

Natural product-derived therapy for cardiomyocyte proliferation and heart regeneration: A pharmaceutical mixture encompassing Naringenin, Geniposide and Fortunellin(NGF) decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up regulation of its target gene, 20/April/2018, 3.21 pm

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory […]
April 20, 2018

Olive oil-based therapy for Deafness: A therapeutic mix encompassing Hydroxytyrosol, Cholecalciferol, Ajoene and DIM (HTCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 20/April/2018, 2.50 pm

  What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Olive oil-based therapy for Deafness: A therapeutic mix encompassing Hydroxytyrosol, Cholecalciferol, Ajoene and DIM (HTCAD) increases […]

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Dr Boominathan’s quote on Science

Science is not about how to follow the conventions, but about how not to follow the conventions