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Total no of Ideas: 9609
Natural product-based therapy for ageing-associated diseases: A therapeutic mix encompassing Lutein, Antacin C & Hesperidin (LAH), isolated from Kale, Antrodia cinnamomea, and Oranges, respectively, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down regulation of its target gene, 19/October/2017, 1.49 am
Natural product therapy for pulmonary arterial hypertension: A therapeutic mix encompassing Curcumin and Quercetin, isolated from Turmeric and Elder berries, respectively, inhibits the development of pulmonary arterial hypertension via down regulation of Notch3 and its target gene Hes-5, 19/October/2017, 1.00 am
Small molecule-based GPC2 pathway blockade enhances the efficacy of Cancer immunotherapy in Neuroblastoma: A therapeutic mix encompassing Ascorbate, Delta-tocotrienol, Dehydroleucodine, & Forodesine [ADDF] inhibits the expression of GPC2, inhibits neuroblastoma proliferation, increases IFNγ signalling, increase antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 18/October/2017, 11.27 pm
Natural product-based therapy for Deafness: A therapeutic mix encompassing Salvianolic Acid B, Cardamomin, Cholecalciferol and DIM (SABCCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration, and improves hearing loss via up regulation of its target genes, 18/October/2017, 12.10 am
Natural product-derived therapy for anxiety and depression: Artesunate, isolated from Artemisia annua L among others, decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression via down regulation of its target gene, 17/October/2017, 11.40 pm
Natural product therapy for Glaucoma: Isorhapontigenin, isolated from Genetum and Norway spruce (Picea abies), and sitka spruce (Picea sitchensis), among others, increases Nmnat1 expression, increases NAD+ levels, improves neuroanl dysfunction, and protects against glaucoma via down regulation of its target gene, 17/October/2017, 11.34 pm
Natural product-derived therapy for Stroke: Glabridin, isolated from Licorice/Glycyrrhiza glabra L, which is used as a food additive (Sweetener), attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via up regulation of its target genes BDNF and NAMPT, 17/October/2017, 11. 23 pm
Xenon-based therapy for Non-alcoholic fatty liver disease (NAFLD): Xenon promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 17/October/2017, 12.58 am
Natural product-derived combination therapy for blood-stage Plasmodium infection: A therapeutic mix encompassing Magnolol, Atovaquone, and Honokiol [MAH] decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via up regulation of its target gene, 17/October/2017, 12.50 am
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Ideas can even be life changing.
We generate bio-medical/pharma/therapeutic/clinical ideas for the scientific community. Good Ideas are uncommon and unique. This is because everyone’s educational background is different. As a result, every one’s thinking process is different. Consequently, his/her ability to connect/understand complex biological/pathological mechanism differs.