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Total no of Ideas: 10521
Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Sitagliptin (trade name: Januvia), a DPP4 inhibitor, increases the expression of tumor suppressors genes, such as p53, TA-p73 and TA-p63, BTG2 and INK4a, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 16/June/2017, 11.48 pm
The miracle herb Holy basil (Tulsi) may help you live longer: Ursolic acid-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Ursolic acid, Catalpol, Isoliquiritigenin, Maresin, DIM, Ursolic acid Lutein, Maresin, Cholecalciferol (UCIMDULMC) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 16/June/2017, 11.30 pm
Natural product-derived therapy for cardiac hypertrophy and fibrosis: A pharmaceutical mixture encompassing βCryptoxanthin, Mangiferin & Glycyrrhetinic acid (CMG) decreases MiR-29 expression, activates wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1 and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via up regulation of its target gene, 16/June/2017, 7.07 pm
Carbon monoxide-based therapy for body weight control, energy homeostasis and TIIDM: COR-M2( CO releasing molecule-2 )inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 14/June/2018, 11.18 pm
Carbon monoxide-based therapy for autoimmune diabetes (TIDM): Carbon monoxide (CO) releasing molecules-2 (COR-M2) increases the expression of PD-L1, augments Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 13/June/2018, 9.23 am
Optimal sleep is required to lead a diabetics-free life: Melatonin-based therapy for diabetes (TIIDM): Melatonin [N-acetyl-5-methoxy tryptamine], a hormone that regulates sleep and wakefulness, increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 13/June/2018, 8.29 am
Carbon monoxide therapy for TIIDM and obesity-associated metabolic deficits: COR-M2(CO releasing molecule-2) increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 12/June/2018, 9.31 pm
Treating blood sugar disease with low-calorie sweeteners: Xylitol-based therapy for diabetes (TIIDM): Xylitol , a low-calorie sweetener isolated from natural products, increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 12/June/2018, 9.23 pm
Combinatorial therapy for Diabetic retinopathy: A pharmaceutical mixture encompassing α-Galactosylceramide, Epicatechin and Matrine (GCEM) inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down regulation of its target gene, 9/June/2018, 10.49 pm
CD24-based therapy for cardiomyocyte proliferation and heart regeneration: Cluster of Differentiation(CD-24) decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up regulation of its target gene, 9/June/2018, 10.41 pm,
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Ideas can even be life changing.
We generate bio-medical/pharma/therapeutic/clinical ideas for the scientific community. Good Ideas are uncommon and unique. This is because everyone’s educational background is different. As a result, every one’s thinking process is different. Consequently, his/her ability to connect/understand complex biological/pathological mechanism differs.