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Total no of Ideas: 10668
A Relaxin(g)-way to say no to cardiac diseases: Relaxin-based therapy for attenuating pathogenesis-associated with Myocardial infarction: Relaxin, a reproductive hormone, decreases IRF3 (Interferon regulatory transcription factor-3), GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival, via up-regulation of its target gene, 18/August/2018, 1.11 am
Unknown function of the known steroid hormone in targeting cancer stem cells in Myeloid leukaemia (ML): Progesterone (P4), a steroid hormone, inhibits cytosolic aminotransferase BCAT1 expression, increases a-ketoglutarate levels, promotes degradation of HIF1a levels, increases DNA demethylase levels, promotes hypomethylation, increases the expression of tumor suppressor genes, inhibits leukaemia-initiating potential of AML cells, promotes differentiation of AML cells, and inhibits cancer progression in AML via up-regulation of its target gene, 18/August/2017, 12.31 am
The contraceptive/birth control pill component Progestin may extend lifespan and healthspan: Progestin, one of the components of contraceptives and birth control pills, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target gene, 18/August/2017, 12.14 am
Relax (in) your way to say no to myocardial diseases: Relaxin-based therapy for cardiac repair and myocardial infarction: Relaxin, a reprodutive hormone, increases Agrin expression, activates Yap and ERK-mediated signaling, replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 17/August/2018, 11.59 pm
Unknown function of the known reproductive hormone Progesterone (P4) in Anti-metastasis therapy: Progesterone (P4), an endogenous steroid hormone, inhibits the expression of a number of enzymes in the glycolytic cycle and suppresses proliferation, migration, invasion, tumorigenesis, and metastasis, via upregulation of its target gene, 17/August/2018, 11.45 am
Relax(in) your way to keep the cardiac diseases at bay: Relaxin-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Relaxin, a reproductive hormone, increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes via down-regulation of its target gene, 17/August/2018, 11.19 pm
Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as TIMP3, CCM3/KRIT1, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 17/August/2018, 10.55 pm
Combinatorial therapy for Metastatic ovarian cancers: A therapeutic mix encompassing Salinomycin, Amitriptyline, Temozolomide, Berberine, Rosuvastatin, Carboplatin, Paclitaxel, and 17-DMAG (SATBRCPD) inhibits the expression of FABP4, increases the expression of a number of tumor suppressor genes, and stifles the metastatic potential and the progression of ovarian cancers, via up-regulation of its target gene, 14/August/2017, 8.37 am
Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as TPM1, INK4a/ARF, TA-p73, TA-p63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 13/August/2018, 10.41 pm
Contraceptive pills may aid in the treatment of blood-stage Plasmodium infection: Progestin, one of the components of birth control/contraceptive pills, decreases the expression of CTLA-4, PD-L1, and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via upregulation of its target gene, 13/August/2018, 6.52 pm
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Ideas can even be life changing.
We generate bio-medical/pharma/therapeutic/clinical ideas for the scientific community. Good Ideas are uncommon and unique. This is because everyone’s educational background is different. As a result, every one’s thinking process is different. Consequently, his/her ability to connect/understand complex biological/pathological mechanism differs.