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 Total no of Ideas: 11106 
January 23, 2019

Ribonucleic acid-based therapy for enhancing memory and cognition:  LncRNA DIGIT increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 23/January/2019, 11.41 am

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center […]
January 23, 2019

Probiotic-based therapy for body weight control, energy homeostasis, and TIIDM: Probiotic Lactobacillus Pentosus var. Plantarum C29 increases REV-ERB and its downstream target genes, inhibits lipid accumulation, improves dyslipidemia and insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 23/January/2019, 9.57 am

Introduction: What they say A study from the Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA shows that “Regulation of circadian behaviour […]
January 22, 2019

Combinatorial therapy for Deafness: A therapeutic mix encompassing Lactobacillus plantarum AR501, Cholecalciferol, Ajoene and DIM (LPARCAD)  increases the expression of ATG5 (Autophagy-ated 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 23/January/2019, 12,04 am

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Combinatorial therapy for Deafness: A therapeutic mix encompassing Lactobacillus plantarum AR501, Cholecalciferol, Ajoene and DIM (LPARCAD)  increases […]
January 22, 2019

Ribonucleic acid-based therapy for autoimmune diabetes: LncRNA CASC9 increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up-regulation of its target gene, 22/January/2018, 11.35 pm

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical […]
January 22, 2019

 Ribonucleic acid-based therapy for enhancing memory and cognition:  LncRNA CYTOR increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 22/January/2019, 11.23 pm

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center […]
January 22, 2019

Treating cardiac diseases with Zhenbao pill: Zhenbao pill-based therapy for Cardiomyopathy: Zhenbao pill decreases the expression of Sox6, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy, via up regulation of its target gene, 22/January/2019, 11.05 pm

Introduction: What they say   A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart […]
January 22, 2019

Probiotic-based therapy for lowering cholesterol, and triglycerides levels:  Lactobacillus Paracasei OFS 0291(LP-0291) decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via up-regulation of its target gene, 22/January/2018, 10.19 pm

The significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 […]
January 19, 2019

Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing Mevastatin, an antipsychotic drug, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as TPM1,PDCD4,  p53, p21, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 19/January/2018, 5.33 pm

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that: Probiotic-based chemotherapy targeting cancer stem cells […]
January 17, 2019

Probiotic-based therapy for lowering cholesterol, and triglycerides levels: Bifidobacterium lactis HY8101 decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via up-regulation of its target gene, 18/December/2018, 12.10 am

The significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 […]
January 17, 2019

RNA-based therapy for aging-associated diseases and Lifespan extension: LncRNA UCA1  inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging, via down-regulation of its target gene, 18/January/2019, 12.04 am

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
January 17, 2019

Probiotic-based therapy for lowering cholesterol, and triglycerides levels: Lactobacillus fermentum DR9 (LF-DR9) decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via up-regulation of its target gene, 17/December/2018, 11.55 pm

The significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 […]
January 17, 2019

RNA-based therapy for aging-associated diseases and Lifespan extension: LncRNA MALAT/NEAT2  inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging, via down-regulation of its target gene, 17/January/2019, 11.48 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]

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Dr Boominathan’s quote on Science

Science is not about how to follow the conventions, but about how not to follow the conventions