Genome Discovery

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 Total no of Ideas: 9234 
July 26, 2017

Natural product-derived Ptpn2 pathway blockade enhances the efficacy of Cancer immunotherapy: Artemisinin, isolated from Artemisia Annua L, inhibits the expression of protein tyrosine phosphatase PTPN2, increases interferon-IFNγ signalling, augments antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 27/July/2017, 1.00 pm

Introduction:What they say: A recent study from Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA; Broad Institute of Harvard and Massachusetts Institute of […]
July 26, 2017

Molecular therapy for glioblastoma: MiRNA-340  inhibits the expression of JMJD6, impairs functioning of transcription elongation machinery, inhibits the proliferation of glioblastoma cells, suppresses tumor cell migration, reduces metastasis and prolongs survival via down regulation of its target gene, 27/July/2017,  12.54 am

Introduction: What they say: A study from the Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Ohio, USA shows that “Transcription elongation factors represent in vivo […]
July 26, 2017

Natural product-derived regenerative therapy for muscular atrophy: Tangretin, isolated from Citrus fruits,  increases the expression of IGF-1, PI3K(p85a) and B-Myb, decreases the expression of tumor suppressors, promotes regeneration of muscle cells, and reverses muscle atrophy via up regulation of its target gene, 26/July/2017, 11.59 pm

Introduction: What they say A study from the Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai 200444, China shows that “miR-29b contributes to multiple types of muscle […]
July 26, 2017

Natural product-derived therapy for muscle atrophy and wasting: Wedelolactone, one of the components of Eclipta Alba, increases the expression of FGF19 and its receptor ß-Klotho, phosphorylates ERK1/2 and S6K1, decreases the expression of tumor suppressors  genes, promotes regeneration of muscle cells and hypertrophy of skeletal muscle, and reverses muscular atrophy and wasting via up regulation of its target gene, 26/July/2017, 11.53 am

Introduction: What they say A study from Department of Biology, University of Bergen, Bergen, Norway; and Univ-Lyon, CarMeN Laboratory, INSERM 1060, INRA 1397, Université Claude Bernard […]
July 26, 2017

 Natural product-derived therapy for prostate cancer: Magnolol, one of the components of Magnolol Grandiflora (MG), inhibits the expression of mTORC1 and its downstream target AMD1, dismantles mTORC1-AMD1 signaling network, decreases polyamine levels, and inhibits prostate cancer progression via up regulation of its target gene, 26/July/2017, 11.44 pm

Introduction: What they say: A study from CIC bioGUNE (Center for Cooperative Research in Biosciences), Bizkaia Technology Park, 801 Building, 48160 Derio, Spain shows that “mTORC1-dependent AMD1 regulation sustains polyamine […]
July 25, 2017

Natural product-derived Ptpn2 pathway blockade enhances the efficacy of Cancer immunotherapy: Honokiol, isolated from Magnolia grandiflora, inhibits the expression of protein tyrosine phosphatase PTPN2, increases interferon-IFNγ signalling, augments antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 25/July/2017, 2.23 pm

Introduction:What they say: A recent study from Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA; Broad Institute of Harvard and Massachusetts Institute of […]
July 25, 2017

The PD-1 pathway activation for Pain therapy: Ursodeoxycholic acid  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 25/July/2017, 12.26  pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
July 25, 2017

Amino acid therapy for Diabetic nephropathy (DN): Taurine ( amino sulfonic acid), the most abundant amino acid, increases Pyruvate kinase M2 (PKM2) expression, decreases toxic glucose metabolites, mitochondrial dysfunction and apoptosis, augments glycolytic flux and PGC-1α levels, improves metabolic abnormalities, albuminuria, glomerular pathology, and renal dysfunction and alleviates diabetic nephropathy via down regulation of its target gene, 25/July/2017, 11.51 am

Introduction: What they say A study from the Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA shows that “Pyruvate kinase M2 activation may protect against the […]
July 25, 2017

 Hyperbaric oxygen (HBO2)-based therapy for Stroke: Hyperbaric oxygen (HBO2) attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via up regulation of its target genes BDNF and NAMPT., 25/July/2017, 11.38 am

Introduction: What they say A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and […]
July 25, 2017

Folate-based regenerative therapy for reversing diabetes: Folic acid increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D via down regulation of its target gene, 25/July/2017, 11.00 am

Introduction: What they say A study from the Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, California, USA; and Koch Institute […]
July 25, 2017

 Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Beraprost sodium increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene, 25/July/2017, 10.50 am

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
July 23, 2017

Hydrogen Sulfide (H2S)-based regenerative therapy for improving memory in aged individuals: Hydrogen Sulfide (H2S) increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning via down regulation of its target genes, 24/July/2017, 12.26 am

Introduction: What they say A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center […]

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