Cancer

Unknown function of the known reproductive hormone Progesterone (P4) in Anti-metastasis therapy: Progesterone (P4), an endogenous steroid hormone, inhibits the expression of a number of enzymes in the glycolytic cycle and suppresses proliferation, migration, invasion, tumorigenesis, and metastasis, via upregulation of its target gene, 17/August/2018, 11.45 am
Unknown function of the known reproductive hormone Progesterone (P4) in Anti-metastasis therapy: Progesterone (P4), an endogenous steroid hormone, inhibits the expression of a number of enzymes in the glycolytic cycle and suppresses proliferation, migration, invasion, tumorigenesis, and metastasis, via upregulation of its target gene, 17/August/2018, 11.45 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102,…

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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  TIMP3, CCM3/KRIT1, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 17/August/2018, 10.55 pm
Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  TIMP3, CCM3/KRIT1, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 17/August/2018, 10.55 pm 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  TPM1, INK4a/ARF, TA-p73, TA-p63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 13/August/2018, 10.41 pm
Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  TPM1, INK4a/ARF, TA-p73, TA-p63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 13/August/2018, 10.41 pm 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others,  increases the expression of tumor suppressors genes, such as  RhoB, p57Kip2, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 11/August/2018, 10.17 pm
Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others,  increases the expression of tumor suppressors genes, such as  RhoB, p57Kip2, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 11/August/2018, 10.17 pm 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others,  increases the expression of tumor suppressors genes, such as  PTPN14, Rb1, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 10/August/2018, 11.03 am
Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others,  increases the expression of tumor suppressors genes, such as  PTPN14, Rb1, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 10/August/2018, 11.03 am 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Combinatorial therapy for gynecologic cancers: A therapeutic mix encompassing  Gedunine, Dianhydrogalactitol, EGCG, Salinomycin, Simvastatin and Fluoxetine (GDESSF) inhibits the expression of HDAC6, acetylates tumor suppressor proteins, activates tumor suppressor function, and stifles the progression of ARID1A-mutated ovarian cancers via up-regulation of its target gene, 8/August/2018, 10.14 pm
Combinatorial therapy for gynecologic cancers: A therapeutic mix encompassing  Gedunine, Dianhydrogalactitol, EGCG, Salinomycin, Simvastatin and Fluoxetine (GDESSF) inhibits the expression of HDAC6, acetylates tumor suppressor proteins, activates tumor suppressor function, and stifles the progression of ARID1A-mutated ovarian cancers via up-regulation of its target gene, 8/August/2018, 10.14 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA shows that “ARID1A-mutated ovarian cancers depend on HDAC6 activity” This study…

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