Cancer

Natural product-based combination therapy targeting cancer stem cells in Myeloid leukaemia (ML): A therapeutic mix encompassing Artemisinin, Glimepiride, Fenofibrate and Calcitriol inhibits cytosolic aminotransferase BCAT1 expression, increases a-ketoglutarate levels, promotes degradation of HIF1a levels, increases DNA demethylase levels, promotes hypomethylation, increases the expression of tumor suppressor genes, inhibits leukaemia-initiating potential of AML cells, promotes differentiation of AML cells, and inhibits cancer progression in AML via up-regulation of its target gene, 19/November/2017, 11.41 pm
Natural product-based combination therapy targeting cancer stem cells in Myeloid leukaemia (ML): A therapeutic mix encompassing Artemisinin, Glimepiride, Fenofibrate and Calcitriol inhibits cytosolic aminotransferase BCAT1 expression, increases a-ketoglutarate levels, promotes degradation of HIF1a levels, increases DNA demethylase levels, promotes hypomethylation, increases the expression of tumor suppressor genes, inhibits leukaemia-initiating potential of AML cells, promotes differentiation of AML cells, and inhibits cancer progression in AML via up-regulation of its target gene, 19/November/2017, 11.41 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction to what they say: A study from the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, German…

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Small molecule-based GPC2 pathway blockade enhances the efficacy of Cancer immunotherapy in Neuroblastoma: A therapeutic mix encompassing Salinomycin, EGCG, Temozolomide, & Magnolol [SETM] inhibits the expression of GPC2, increases IFNγ signalling, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, inhibits neuroblastoma proliferation, decreases tumor burden and increases survival via up-regulation of its target gene, 21/October/2017, 8.17 am
Small molecule-based GPC2 pathway blockade enhances the efficacy of Cancer immunotherapy in Neuroblastoma: A therapeutic mix encompassing Salinomycin, EGCG, Temozolomide, & Magnolol [SETM] inhibits the expression of GPC2, increases IFNγ signalling, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, inhibits neuroblastoma proliferation, decreases tumor burden and increases survival via up-regulation of its target gene, 21/October/2017, 8.17 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA shows that “Identification of…

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Small molecule-based GPC2 pathway blockade enhances the efficacy of Cancer immunotherapy in Neuroblastoma: A therapeutic mix encompassing Ascorbate, Delta-tocotrienol, Dehydroleucodine, & Forodesine [ADDF] inhibits the expression of GPC2, increases IFNγ signalling, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, inhibits neuroblastoma proliferation, decreases tumor burden and increases survival via up-regulation of its target gene, 18/October/2017, 11.27 pm
Small molecule-based GPC2 pathway blockade enhances the efficacy of Cancer immunotherapy in Neuroblastoma: A therapeutic mix encompassing Ascorbate, Delta-tocotrienol, Dehydroleucodine, & Forodesine [ADDF] inhibits the expression of GPC2, increases IFNγ signalling, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, inhibits neuroblastoma proliferation, decreases tumor burden and increases survival via up-regulation of its target gene, 18/October/2017, 11.27 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA shows that “Identification of…

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Natural product-derived CDK4/6 pathway blockade enhances the efficacy of Cancer immunotherapy: A pharmacological mixture encompassing Zinc metallochaperone-1 (ZMC1), Formononetin, Apigenin, EGCG, Chloroquine, Tubascin, Triptolide, Temozolomide, Cholecalciferol, Dehydroleucodine, PEITC, & Linalool  (ZMC1FAECTTTCDPL) inhibits the expression of cell cycle protein CDK4/CDK6, increases levels of T-III IFNs, inhibits the proliferation of Treg cells, decreases DNMT1 expression, inhibits the expression of a number of immune evasion molecules, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target genes, 16/October/2017, 12.33 am
Natural product-derived CDK4/6 pathway blockade enhances the efficacy of Cancer immunotherapy: A pharmacological mixture encompassing Zinc metallochaperone-1 (ZMC1), Formononetin, Apigenin, EGCG, Chloroquine, Tubascin, Triptolide, Temozolomide, Cholecalciferol, Dehydroleucodine, PEITC, & Linalool  (ZMC1FAECTTTCDPL) inhibits the expression of cell cycle protein CDK4/CDK6, increases levels of T-III IFNs, inhibits the proliferation of Treg cells, decreases DNMT1 expression, inhibits the expression of a number of immune evasion molecules, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target genes, 16/October/2017, 12.33 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands has identified CMTM6 and CMTM4 as…

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Natural product-derived therapy for prostate cancer bone metastasis: A therapeutic mix encompassing Nimbolide and Solasodine, isolated from Azadirachta indica, and Solarium melongena, respectively,  inhibits the expression of Monoamine oxidase A (MAOA), inhibits Shh-IL6-RANKL signaling network, suppresses tumor-stromal interactions, reduces prostate cancer metastasis and prolongs survival via up regulation of its target gene, 04/October/2017, 11.59 pm
Natural product-derived therapy for prostate cancer bone metastasis: A therapeutic mix encompassing Nimbolide and Solasodine, isolated from Azadirachta indica, and Solarium melongena, respectively,  inhibits the expression of Monoamine oxidase A (MAOA), inhibits Shh-IL6-RANKL signaling network, suppresses tumor-stromal interactions, reduces prostate cancer metastasis and prolongs survival via up regulation of its target gene, 04/October/2017, 11.59 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Uro-Oncology Research Program, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA shows that “MAOA-Dependent Activation of Shh-IL6-RANKL Signaling Network Promotes…

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Natural product-derived CDK4/6 pathway blockade enhances the efficacy of Cancer immunotherapy: A pharmacological mixture encompassing Mevastatin, Desipramine, EGCG, Decitabine, Biochanin A, Temozolomide (TMZ) , Cholecalciferol, PEITC, & Linalool (MDEBTCPL)  inhibits the expression of cell cycle protein CDK4/CDK6, increases levels of T-III IFNs, inhibits the proliferation of Treg cells, decreases DNMT1 expression, inhibits the expression of a number of immune evasion molecules, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target genes, 04/October/2017, 11.04 pm
Natural product-derived CDK4/6 pathway blockade enhances the efficacy of Cancer immunotherapy: A pharmacological mixture encompassing Mevastatin, Desipramine, EGCG, Decitabine, Biochanin A, Temozolomide (TMZ) , Cholecalciferol, PEITC, & Linalool (MDEBTCPL)  inhibits the expression of cell cycle protein CDK4/CDK6, increases levels of T-III IFNs, inhibits the proliferation of Treg cells, decreases DNMT1 expression, inhibits the expression of a number of immune evasion molecules, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target genes, 04/October/2017, 11.04 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands has identified CMTM6 and CMTM4 as…

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