Cancer

August 23, 2017

Natural product-derived combinatorial therapy for therapy-resistant cancers: A therapeutic mix encompassing Berberine (BER), Gambogic acid and Curcumin (BGC) inhibits the expression of phospholipid glutathione peroxidase (GPX4), inhibits GPX4 signaling network and lipid peroxidase pathway, suppresses EMT protein ZEB1, increases sensitivity to anticancer therapy and prolongs survival via up regulation of its target gene, 24/August/2017, 12.33 am

Introduction: What they say: A study from Broad Institute, Cambridge, Massachusetts, USA, Howard Hughes Medical Institute, Chevy Chase, Maryland and Department of Chemistry and Chemical Biology, […]
August 23, 2017

Molecular therapy for Metastatic cancers: Myrtenal, isolated  from Taxus, increases the expression of metastasis suppressors TIMP3 and CCM3/KRTI1, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 24/August/2017, 12.24 am

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
August 22, 2017

Natural product/vitamin-based Combination therapy for PTEN-deficient cancer: A therapeutic mix encompassing Artemisinin, Cholecalciferol and Metformin decreases the expression of CHD1, increases the expression of a number of tumor suppressor genes, inhibits pro-survival TNF-NF-kB gene network, and suppresses tumorigenesis of PTEN-deficient cancer, 22/August/2017, 10.29 pm

Introduction: What they say: A study from the Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA shows that “Synthetic […]
August 22, 2017

Natural product-derived therapy for prostate cancer: A therapeutic mix encompassing N-Acetylcysteine(NAC), Capsaicin, and Sulforaphane (NCS) inhibits the expression of mTORC1 and its downstream target AMD1, dismantles mTORC1-AMD1 signaling network, decreases polyamine levels, and inhibits prostate cancer progression via up regualtion of its target gene, 22/July/2017, 10.08 pm

Introduction: What they say: A study from CIC bioGUNE (Center for Cooperative Research in Biosciences), Bizkaia Technology Park, 801 Building, 48160 Derio, Spain shows that “mTORC1-dependent AMD1 regulation sustains polyamine […]