Cancer

Natural product-derived Anti-AXL therapeutics for enhancing the efficacy of chemotherapies: Combination of Solosodine and Matrine, found in solanum melongena and Sophora, respectively, decreases the expression of the AXL receptor and its activating ligand, GAS6, increases the expression of a number of tumor suppressor genes, increases therapeutic index of anticancer drugs, suppresses tumorigenesis, migration, invasion, and metastasis via up regulation of its target gene, 9/July/2017, 11.58 pm
Natural product-derived Anti-AXL therapeutics for enhancing the efficacy of chemotherapies: Combination of Solosodine and Matrine, found in solanum melongena and Sophora, respectively, decreases the expression of the AXL receptor and its activating ligand, GAS6, increases the expression of a number of tumor suppressor genes, increases therapeutic index of anticancer drugs, suppresses tumorigenesis, migration, invasion, and metastasis via up regulation of its target gene, 9/July/2017, 11.58 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Department of Radiation Oncology, Stanford University School of Medicine shows that “Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.” This study was published…

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Natural product therapy for CyclinD3-CDK6 overexpressing cancers: Epigallocatechin-3-gallate (EGCG), isolated from Green tea, increases the levels of tumor suppressor proteins, inhibits the activity of glycolytic enzymes 6-phosphofructokinase and pyruvate kinase M2, decreases antioxidants NADPH and glutathione levels, increases reactive oxygen species levels, promotes apoptosis, and inhibits the progression of CyclinD3-CDK6 overexpressing cancers via down regulation of its target gene, 9/July/2017, 11.46 pm
Natural product therapy for CyclinD3-CDK6 overexpressing cancers: Epigallocatechin-3-gallate (EGCG), isolated from Green tea, increases the levels of tumor suppressor proteins, inhibits the activity of glycolytic enzymes 6-phosphofructokinase and pyruvate kinase M2, decreases antioxidants NADPH and glutathione levels, increases reactive oxygen species levels, promotes apoptosis, and inhibits the progression of CyclinD3-CDK6 overexpressing cancers via down regulation of its target gene, 9/July/2017, 11.46 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; and Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA shows that “The metabolic function of…

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Anti-telomerase cancer therapy: Interleukin-23 (IL-23) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 9/July/2017, 11.40 pm
Anti-telomerase cancer therapy: Interleukin-23 (IL-23) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 9/July/2017, 11.40 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and…

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Natural product-derived therapy for prostate cancer: Shikonin, one of the components of Zicao, inhibits the expression of mTORC1 and its downstream target AMD1, dismantles mTORC1-AMD1 signaling network, decreases polyamine levels, and inhibits prostate cancer progression via up regualtion of its target gene, 9/July/2017, 12.09 am
Natural product-derived therapy for prostate cancer: Shikonin, one of the components of Zicao, inhibits the expression of mTORC1 and its downstream target AMD1, dismantles mTORC1-AMD1 signaling network, decreases polyamine levels, and inhibits prostate cancer progression via up regualtion of its target gene, 9/July/2017, 12.09 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from CIC bioGUNE (Center for Cooperative Research in Biosciences), Bizkaia Technology Park, 801 Building, 48160 Derio, Spain shows that “mTORC1-dependent AMD1 regulation sustains polyamine…

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Anti-telomerase cancer therapy: α-Solanine, isolated from Solanum Nigrum, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 8/July/2017, 11.33 pm
Anti-telomerase cancer therapy: α-Solanine, isolated from Solanum Nigrum, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 8/July/2017, 11.33 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech, from the BioFrontiers Institute, USA, has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: 43) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and…

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Natural product-derived therapy for Human Leukemias: Dihydromyricetin, isolated from Ampeopsis Grossdentatam, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 7/July/2017, 10.23 pm
Natural product-derived therapy for Human Leukemias: Dihydromyricetin, isolated from Ampeopsis Grossdentatam, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 7/July/2017, 10.23 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce…

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