Natural product-derived Combination therapy for Squamous cell carcinoma of head and neck (HNSCC): A therapeutic mix encompassing an anticancer drug, 1,25-dihydroxyvitamin D and Artemisinin may decrease BMI1 and AP-1 expression, overcome chemotherapeutic resistance, promote chemosensitivity, suppress cancer stem cells in HNSCC, and inhibit lymph node metastasis via down regulation of its target genes, 26/June/2017, 10.56 pm

Introduction: What they say: A study from the Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, UCLA, Los Angeles, California, USA shows that inhibition of BMI1+ Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma. This study was published, in the 9 […]

Vitamin-based therapy for EVI-1-Overexpressing Acute Myeloid Leukemia: Cholecalciferol, a form of Vitamin-D3, decreases the expression of MECOM/EVI-1 and its down target genes, including CKMT-1, alters Arginine-creatine metabolism, inhibits mitochondrial respiration, depletes ATP levels, and promotes regression of EVI-1-overexpressing AML via up regulation of its target gene, 24/June/2017, 11.59 pm

Introduction: What they say: A study from the Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; and Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA shows that “The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.” […]

Natural product-derived therapy for Metastatic cancers: Diosmetin, isolated from citrus limon, decreases the expression of metastasis promoters ZBTB2 and PPM1F, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 23/June/2017, 11.37 pm

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) most of the cancer patients die due to metastasis; (iv) cancer treatment causes […]

Natural product-derived therapy for metastatic prostate cancer: Isorhapontigenin, isolated from sitka spruce (Picea sitchensis) and Aiphanes, inhibits the expression of CDC42, CDC42EP3, RAC1 and ARPC5, and GAS6, suppresses the expression of stem cell molecules CD44 and EZH2, promotes epithelial phenotype, suppresses tumorigenesis, migration, invasion, stem cell regeneration and metastasis via up regulation of its target gene, 23/June/2017, 11.33 pm

Introduction: What they say: A study from the Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park, Texas 78957, USA shows that “MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes.” This study was published in the 23 January 2017 issue of the […]

Natural product-derived Anti-AXL therapeutics for enhancing the efficacy of chemotherapies: Combination of Hyperoside and Epigallocatechin-3- gallate, found in Drosera rotundifolia and Green tea, respectively, decreases the expression of the AXL receptor and its activating ligand, GAS6, increases the expression of a number of tumor suppressor genes, increases therapeutic index of anticancer drugs, suppresses tumorigenesis, migration, invasion, and metastasis via up regulation of its target gene, 23/June/2017, 9.49 pm

Introduction: What they say: A study from the Department of Radiation Oncology, Stanford University School of Medicine shows that “Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.” This study was published in the 3 January 2017 issue of the journal “Journal of Clinical Investigations” [one of the best journals General medicine with an […]

Molecular therapy for heart regeneration and repair: Astaxainthin, isolated from heaematococcus pluvialis, Pandalus, and Phaffia, increases Agrin expression, activates Yap and ERK-mediated signaling, replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 22/June/2017, 11.33 pm

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA; and Baylor College of Medicine and The Texas Heart Institute, Houston, Texas 77030, US shows that “The extracellular matrix protein Agrin promotes heart regeneration […]