Cancer

Natural product-derived Anti-AXL therapeutics for enhancing the efficacy of chemotherapies: Combination of Celastrol and Cirsiliol, found in Thunder god vine and achillea fragrantissima, respectively, decreases the expression of the AXL receptor and its activating ligand, GAS6, increases the expression of a number of tumor suppressor genes, increases therapeutic index of anticancer drugs, suppresses tumorigenesis, migration, invasion, and metastasis via up regulation of its target gene, 10/June/2017, 11.57 pm
Natural product-derived Anti-AXL therapeutics for enhancing the efficacy of chemotherapies: Combination of Celastrol and Cirsiliol, found in Thunder god vine and achillea fragrantissima, respectively, decreases the expression of the AXL receptor and its activating ligand, GAS6, increases the expression of a number of tumor suppressor genes, increases therapeutic index of anticancer drugs, suppresses tumorigenesis, migration, invasion, and metastasis via up regulation of its target gene, 10/June/2017, 11.57 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Department of Radiation Oncology, Stanford University School of Medicine shows that “Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.” This…

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Molecular therapy for metastasis: Urocanic acid inhibits the expression of IL-6/8, decreases the expression of down stream molecules WASF3 and Arp2/3, suppresses tumor cell migration, reduces metastasis and prolongs survival via up regulation of its target gene, 9/June/2017, 11.56 pm
Molecular therapy for metastasis: Urocanic acid inhibits the expression of IL-6/8, decreases the expression of down stream molecules WASF3 and Arp2/3, suppresses tumor cell migration, reduces metastasis and prolongs survival via up regulation of its target gene, 9/June/2017, 11.56 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA; Johns Hopkins Physical Sciences-Oncology Center, The Johns Hopkins University,…

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Natural product therapy for KRAS/LKB1-mutant lung cancer: Rhamnetin, isolated from cloves, increases the levels of tumor suppressor proteins, inhibits the expression of urea cycle enzyme carbamoyl phosphate synthetase-1 (CSP1), decreases pyrimidine pools, stalls DNA synthesis, and inhibits the progression of KRAS/LKB1-mutated lung cancers via up regulation of its target gene, 8/June/2017, 11. 34 pm
Natural product therapy for KRAS/LKB1-mutant lung cancer: Rhamnetin, isolated from cloves, increases the levels of tumor suppressor proteins, inhibits the expression of urea cycle enzyme carbamoyl phosphate synthetase-1 (CSP1), decreases pyrimidine pools, stalls DNA synthesis, and inhibits the progression of KRAS/LKB1-mutated lung cancers via up regulation of its target gene, 8/June/2017, 11. 34 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Children’s Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390, USA; Department of Pediatrics, UT Southwestern Medical Center, Dallas, Texas…

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Molecular therapy for Chronic Myeloid leukaemia (CML): BMP4 (Bone Morphogenic protein-4) decreases the expression of Musashi2, inhibits cytosolic aminotransferase BCAT1 expression, decreases the intracellular production of BCAAs (Branched-chain amino acids), increases the expression of tumor suppressor genes, promotes differentiation of CML cells, and inhibits cancer progression in Myeloid leukemia via up-regulation of its target gene, 8/June/2017, 11.29 pm
Molecular therapy for Chronic Myeloid leukaemia (CML): BMP4 (Bone Morphogenic protein-4) decreases the expression of Musashi2, inhibits cytosolic aminotransferase BCAT1 expression, decreases the intracellular production of BCAAs (Branched-chain amino acids), increases the expression of tumor suppressor genes, promotes differentiation of CML cells, and inhibits cancer progression in Myeloid leukemia via up-regulation of its target gene, 8/June/2017, 11.29 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Department of Biochemistry-Molecular Biology, Franklin College of Arts and Sciences, The University of Georgia, Athens, Georgia 30602, USA; and The University of…

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Natural product therapy for KRAS/LKB1-mutant lung cancer: Cirsilol, isolated from Achillea Fragrantissima, increases the levels of tumor suppressor proteins, inhibits the expression of urea cycle enzyme carbamoyl phosphate synthetase-1 (CSP1), decreases pyrimidine pools, stalls DNA synthesis, and inhibits the progression of KRAS/LKB1-mutated lung cancers via up regulation of its target gene, 6/June/2017, 11. 15pm
Natural product therapy for KRAS/LKB1-mutant lung cancer: Cirsilol, isolated from Achillea Fragrantissima, increases the levels of tumor suppressor proteins, inhibits the expression of urea cycle enzyme carbamoyl phosphate synthetase-1 (CSP1), decreases pyrimidine pools, stalls DNA synthesis, and inhibits the progression of KRAS/LKB1-mutated lung cancers via up regulation of its target gene, 6/June/2017, 11. 15pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Children’s Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390, USA; Department of Pediatrics, UT Southwestern Medical Center, Dallas, Texas…

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Natural product-derived therapy for metastasis: Berberine, one of the components of Berberis, Phellodendron amurense, and Guduchi among others, inhibits the expression of IL-6/8, decreases the experssion of down stream molecules WASF3 and Arp2/3, suppresses tumor cell migration, reduces metastasis and prolongs survival via up regulation of its target gene, 6/June/2017, 11.14 pm
Natural product-derived therapy for metastasis: Berberine, one of the components of Berberis, Phellodendron amurense, and Guduchi among others, inhibits the expression of IL-6/8, decreases the experssion of down stream molecules WASF3 and Arp2/3, suppresses tumor cell migration, reduces metastasis and prolongs survival via up regulation of its target gene, 6/June/2017, 11.14 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA; Johns Hopkins Physical Sciences-Oncology Center, The Johns Hopkins University,…

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