Ideas

Molecular therapy for aging-associated diseases and Lifespan extension: Rosuvastatin, an anti-dyslipidemic drug used to treat lower cholesterol levels and cardiovascular disease,, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down regulation of its target gene, 14/November/2018, 11.48 pm
Molecular therapy for aging-associated diseases and Lifespan extension: Rosuvastatin, an anti-dyslipidemic drug used to treat lower cholesterol levels and cardiovascular disease,, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down regulation of its target gene, 14/November/2018, 11.48 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and Department of Pharmacology, School…

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Astrocyte-derived neurotrophic factor comes to the rescue of Diabetes Mellitus: MANF (Mesencephalic astrocyte-derived neurotrophic factor) augments the expression of FGF19 and FGF1,  attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM via upregulation of its target gene, 14/October/2018, 3.38 pm
Astrocyte-derived neurotrophic factor comes to the rescue of Diabetes Mellitus: MANF (Mesencephalic astrocyte-derived neurotrophic factor) augments the expression of FGF19 and FGF1,  attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM via upregulation of its target gene, 14/October/2018, 3.38 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say  A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection of FGF1 induces sustained…

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Mechanistic insights into how ADNP enhances learning, memory and cognition: ADNP (Activity-dependent neuroprotective protein) increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 14/November/2018, 3.20 pm
Mechanistic insights into how ADNP enhances learning, memory and cognition: ADNP (Activity-dependent neuroprotective protein) increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 14/November/2018, 3.20 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of…

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Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: MANF (Mesencephalic astrocyte-derived neurotrophic factor)  increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of  its target gene Lin28, 14/November/2018, 3.11 pm
Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: MANF (Mesencephalic astrocyte-derived neurotrophic factor)  increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of  its target gene Lin28, 14/November/2018, 3.11 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study…

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Molecular therapy for Stroke: ADNP (Activity-dependent neuroprotective protein) attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via upregulation of its target genes BDNF and NAMPT, 14/November/2018, 1.22 pm
Molecular therapy for Stroke: ADNP (Activity-dependent neuroprotective protein) attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via upregulation of its target genes BDNF and NAMPT, 14/November/2018, 1.22 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public…

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Probiotic-based therapy for metastatic prostate cancer: Lactobacillus Rhamnosus inhibits the expression of CDC42, CDC42EP3, RAC1 and ARPC5, and GAS6, suppresses the expression of stem cell molecules CD44 and EZH2, promotes epithelial phenotype, suppresses tumorigenesis, migration, invasion, stem cell regeneration and metastasis via upregulation of its target gene, 14/November/2017, 12.59 am
Probiotic-based therapy for metastatic prostate cancer: Lactobacillus Rhamnosus inhibits the expression of CDC42, CDC42EP3, RAC1 and ARPC5, and GAS6, suppresses the expression of stem cell molecules CD44 and EZH2, promotes epithelial phenotype, suppresses tumorigenesis, migration, invasion, stem cell regeneration and metastasis via upregulation of its target gene, 14/November/2017, 12.59 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park, Texas 78957, USA shows that “MicroRNA-141 suppresses…

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