Ideas

Probiotic-based therapy for cancer: Probiotic Lactobacillus rhamnosus inhibits the expression of mTORC1 and its downstream target AMD1, dismantles mTORC1-AMD1 signaling network, decreases polyamine levels, and inhibits prostate cancer progression via upregulation of its target gene, 1/November/2018, 11.39 pm
Probiotic-based therapy for cancer: Probiotic Lactobacillus rhamnosus inhibits the expression of mTORC1 and its downstream target AMD1, dismantles mTORC1-AMD1 signaling network, decreases polyamine levels, and inhibits prostate cancer progression via upregulation of its target gene, 1/November/2018, 11.39 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from CIC bioGUNE (Center for Cooperative Research in Biosciences), Bizkaia Technology Park, 801 Building, 48160 Derio, Spain shows that “mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.” This…

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Probiotic-based therapy targeting cancer stem cells in Myeloid leukaemia (ML): Probiotic Lactobacillus rhamnosus inhibits cytosolic aminotransferase BCAT1 expression, increases a-ketoglutarate levels, promotes degradation of HIF1a levels, increases DNA demethylase levels, promotes hypomethylation, increases the expression of tumor suppressor genes, inhibits leukaemia-initiating potential of AML cells, promotes differentiation of AML cells, and inhibits cancer progression in AML via up-regulation of its target gene, 11/November/2018, 11.13 pm
Probiotic-based therapy targeting cancer stem cells in Myeloid leukaemia (ML): Probiotic Lactobacillus rhamnosus inhibits cytosolic aminotransferase BCAT1 expression, increases a-ketoglutarate levels, promotes degradation of HIF1a levels, increases DNA demethylase levels, promotes hypomethylation, increases the expression of tumor suppressor genes, inhibits leukaemia-initiating potential of AML cells, promotes differentiation of AML cells, and inhibits cancer progression in AML via up-regulation of its target gene, 11/November/2018, 11.13 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction to what they say: A study from the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, German…

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Repurposing the anti-hypertensive agent into a stroke medicine: Aliskiren (Tekturna and Rasilez), a renin inhibitor used in the treatment of hypertension, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up-regulation of its target genes BDNF and NAMPT, 1/November/2018, 4.50 pm
Repurposing the anti-hypertensive agent into a stroke medicine: Aliskiren (Tekturna and Rasilez), a renin inhibitor used in the treatment of hypertension, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up-regulation of its target genes BDNF and NAMPT, 1/November/2018, 4.50 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say  A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public…

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Act(os) against cancer: Pioglitazone (trade name: Actos), an anti-diabetic drug, increases the expression of tumor suppressors genes, such as KIBRA, GAS5, p53,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene,1/November/2018, 4.40 pm
Act(os) against cancer: Pioglitazone (trade name: Actos), an anti-diabetic drug, increases the expression of tumor suppressors genes, such as KIBRA, GAS5, p53,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene,1/November/2018, 4.40 pm 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Repurposing the anti-pulmonary hypertensive drug into a longevity-promoting drug: Valsartan (trade name: Diovan), an anti-pulmonary hypertensive drug, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 1/November/2018, 3.18 pm
Repurposing the anti-pulmonary hypertensive drug into a longevity-promoting drug: Valsartan (trade name: Diovan), an anti-pulmonary hypertensive drug, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 1/November/2018, 3.18 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and Department of Pharmacology, School…

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Probiotics as Exercise mimetics: A probiotic-based exercise mimetic therapy for Metabolic disease: Probiotic Clostridium butyricum CGMCC0313.1 increases PPARδ  and Foxo1 levels, inhibits glucose catabolism, preserves glucose levels, stimulates FA catabolism, delays the onset of hypoglycemia and boosts endurance exercise,  via down-regulation of its target gene, 31/October/2018, 10.24 pm
Probiotics as Exercise mimetics: A probiotic-based exercise mimetic therapy for Metabolic disease: Probiotic Clostridium butyricum CGMCC0313.1 increases PPARδ  and Foxo1 levels, inhibits glucose catabolism, preserves glucose levels, stimulates FA catabolism, delays the onset of hypoglycemia and boosts endurance exercise,  via down-regulation of its target gene, 31/October/2018, 10.24 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say  A study from Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA shows that “CRY1/2 Selectively Repress…

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