Ideas

August 8, 2018

Published by admin_auro at August 8, 2018

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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others, increases the expression of tumor suppressors genes, such as SOCS1/6, TET1, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 8/August/2018, 10.23 pm

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]

August 8, 2018

Published by admin_auro at August 8, 2018

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Cancer
Ideas

Combinatorial therapy for gynecologic cancers: A therapeutic mix encompassing Gedunine, Dianhydrogalactitol, EGCG, Salinomycin, Simvastatin and Fluoxetine (GDESSF) inhibits the expression of HDAC6, acetylates tumor suppressor proteins, activates tumor suppressor function, and stifles the progression of ARID1A-mutated ovarian cancers via up-regulation of its target gene, 8/August/2018, 10.14 pm

Introduction: What they say: A study from Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA shows that “ARID1A-mutated ovarian cancers depend on […]

August 8, 2018

Published by admin_auro at August 8, 2018

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Estrogen-based therapy for body weight control, energy homeostasis and TIIDM: Estradiol (E2) decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 8/August/2018, 9.48 pm

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by […]

August 8, 2018

Published by admin_auro at August 8, 2018

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Reproductive hormone Progesterone 4 (P4) may find its utility in the treatment of anxiety and depression: Progesterone (P4), a reproductive hormone, decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression, via down-regulation of its target gene, 8/August/2018, 9.35 pm

Introduction: What they say: A study from Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; Department […]