Ideas

Natural product therapy for KRAS-mutant lung cancer: α-Lipoic acid decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 11/October/2016, 11.08 pm
Natural product therapy for KRAS-mutant lung cancer: α-Lipoic acid decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 11/October/2016, 11.08 pm 150 150 Dr Boomi's Genom-2-Discovery Center

A recent study from the Department of Cell Biology, University of Texas Southwestern Medical Center, Texas 75390, USA shows that XPO1 can be pharmacologically targeted in KRAS-mutant lung cancer. This study was…

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Natural product Anti-telomerase cancer therapy: Withaferin A (WFA), a natural compound derived from Withania somnifera, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 11/October/2016, 10.48 pm
Natural product Anti-telomerase cancer therapy: Withaferin A (WFA), a natural compound derived from Withania somnifera, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 11/October/2016, 10.48 pm 150 150 Dr Boomi's Genom-2-Discovery Center

The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights…

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Natural product-based cancer therapy: γ-Bisabolene, one of the main components of Cardamom, inhibits cancer development by suppressing the expression of nucleotide sanitizing enzyme MTH1/NUDT1, 11/October/2016, 10.15 pm
Natural product-based cancer therapy: γ-Bisabolene, one of the main components of Cardamom, inhibits cancer development by suppressing the expression of nucleotide sanitizing enzyme MTH1/NUDT1, 11/October/2016, 10.15 pm 150 150 Dr Boomi's Genom-2-Discovery Center

A study from Karolinska Institutet, Stockholm, Sweden shows that “MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.” This study was published in the April 10, 2014 Nature [I.F >42] by Prof. Thomas H, Dr Gad H and…

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Interleukin therapy for Myocardial Infarction: Interleukin-4 improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 11/October/2016, 10.07 pm
Interleukin therapy for Myocardial Infarction: Interleukin-4 improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 11/October/2016, 10.07 pm 150 150 Dr Boomi's Genom-2-Discovery Center

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this…

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Life-extension therapy: MiR-486-5p inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via upregulation of its target genes, 11/October/2016, 10.02 pm
Life-extension therapy: MiR-486-5p inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via upregulation of its target genes, 11/October/2016, 10.02 pm 150 150 Dr Boomi's Genom-2-Discovery Center

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates…

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Natural product therapy for Otitis Media: Neem leaf extract induces MKP-1 expression, inhibits IKKß phosphorylation, suppresses NDHi-induced inflammatory mediator C-X-C motif chemokine ligand 5 (CXCL5) expression, controls overreactive inflammatory responses, inhibits the progression of Otitis media and ameliorates conductive hearing loss via up regulation of its target gene, 11/October/2016, 9.20 pm
Natural product therapy for Otitis Media: Neem leaf extract induces MKP-1 expression, inhibits IKKß phosphorylation, suppresses NDHi-induced inflammatory mediator C-X-C motif chemokine ligand 5 (CXCL5) expression, controls overreactive inflammatory responses, inhibits the progression of Otitis media and ameliorates conductive hearing loss via up regulation of its target gene, 11/October/2016, 9.20 pm 150 150 Dr Boomi's Genom-2-Discovery Center

A study from the Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA shows that: “Curcumin suppresses NTHi-induced CXCL5 expression via inhibition…

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