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 Total no of Ideas: 11665 
February 24, 2020

Molecular therapy for body weight control, energy homeostasis and TIIDM: TICAM1/TRIF[Toll-like receptor adaptor molecule1/TIR-domain-containing adapter-inducing interferon-beta] decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 24/February/2020, 11.12 pm

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by […]
February 22, 2020

Repurposing the anti-hypertensive agent Carvedilol into an anti-HIV agent: Carvedilol (trade name: Coreg and others)) increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 22/February/2020, 11.19 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Repurposing the anti-hypertensive agent Carvedilol into an anti-HIV agent: Carvedilol (trade name: Coreg […]
February 20, 2020

Mechanistic insights into how Blue zone longevity diet protects against cardiac dysfunction: Having honey on a daily basis will protect you against cardiac dysfunction and extend lifespan:Chrysin, found in propolis and honey, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 20/February/2020, 8.10 pm

Idea Proposed/Formulated by: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD. From research findings to Therapeutic opportunity:  Blue zone longevity diet, consumed by long-lived people from blue […]
February 20, 2020

Repurposing the anti-lipidemic agent Fenofibrate into an anti-HIV agent: Fenofibrate  (trade name: Fenoglide, Lipofen, Tricor and others)), an antilipidemic drug, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 20/February/2020, 9.39 am

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Repurposing the anti-lipidemic agent Fenofibrate into an anti-HIV agent: Fenofibrate  (trade name: Fenoglide, Lipofen, […]
January 26, 2020

Taurine-based regenerative therapy for curing Glaucoma: Taurine/2-Aminoethane-1-sulfonic acid increases the expression of genes that promote regeneration,  promotes reprogramming of aged eye cells, increases telomerase expression, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against and reverses glaucoma,  via upregulation of its target gene, 26/January/2019, 11.46 pm

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, […]
January 20, 2020

Mechanistic insights into how Okinawan longevity diet protects against cardiac dysfunction: Having turmeric tea on a daily basis will protect you against cardiac dysfunction and extend lifespan: Curcumin (Diferuloylmethane), found in turmeric, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 20/January/2020, 11.54 pm

Idea Proposed/Formulated by: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD. From research findings to Therapeutic opportunity:  Okinawan longevity diet, consumed by long-lived people from an island […]
January 18, 2020

 Lifespan extension therapy comes of age: Metfomin aids in Lifespan extension: Metformin, the widely prescribed drug in the treatment of type II diabetes, activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, increases adult stem cell proliferation, alleviates ageing feature and extends lifespan, via upregulation of its target genes ATG5 (Autophagy-related 5) and telomerase, 18/January/2020, 11.59 pm

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was […]
January 17, 2020

Sauna/Waon based regenerative cardiovascular therapy: Molecular mechanistic insight into how Sauna/Waon therapy  protects against and promotes functional recovery after Myocardial Infarction:  Sauna(heat/thermal)/Waon therapy inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte proliferation, regeneration and survival after myocardial infarction, via up-regulation of its target gene, 17/January/2019, 10.45 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of […]
January 15, 2020

Probiotic-based Chemotherapy (PCT) targeting cancer stem cells and immune-inhibitory receptors in metastatic breast cancer and in other advanced metastatic cancers: A pharmaceutical mixture encompassing Acarbose [trade name: Glucobay, Precose, Prandase]and probiotic Lactobacillus rhamnosus (ALR) increases the expression of tumor suppressor genes, such as TPM1(Tropomycin1), TIMP3 (TIMP Metallopeptidase Inhibitor 3),  p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance and prolongs survival, and stalls metastatic breast cancer progression, via up-regulation of its target gene, 16/January/2019, 12.11 am

What we say: Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that: Probiotic-based Chemotherapy (PCT) targeting cancer stem cells and immune-inhibitory receptors in metastatic breast […]
January 10, 2020

Marine bacteria aids in heart regeneration and promotes stress resistance: Maritoclax (Marinopyrorle A), found in Marine bacteria, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 10/January/2020, 7.01 am

Idea Proposed/Formulated by: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD. From research findings to Therapeutic opportunity: This study suggests, for the first time, that Maritoclax (Marinopyrorle A), […]
January 9, 2020

Lutin/Zeaxanthin-based regenerative therapy for curing Glaucoma: A pharmaceutical mixture encompassing Lutin & Zeaxanthin  increases the expression of genes that promote regeneration,  promotes reprogramming of aged eye cells, increases telomerase expression, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against and reverses glaucoma,  via up-regulation of its target gene, 9/January/2020, 5.51 am

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, […]
January 8, 2020

Meformin aids in heart regeneration and promotes stress resistance: Metformin, the widely used drug in the treatment of T2DM, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 8/January/2020, 1.58 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Significance: A number of studies suggest that Metformin, the widely used drug in the treatment of T2DM, protects against cardaic […]

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Dr Boominathan’s quote on Science

Science is not about how to follow the conventions, but about how not to follow the conventions