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 Total no of Ideas: 11526 
June 18, 2019
Published by admin_auro at June 18, 2019
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Ciliary neurotrophic factor (CNTF)-based curative therapy for autoimmune diabetes (TIDM):  Ciliary neurotrophic factor (CNTF)  increases the expression of PD-L1, decreases the expression of TXNIP, augments Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 18/June/2019, 10.56 pm

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical […]
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June 17, 2019
Published by admin_auro at June 17, 2019
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Solving a century-old puzzle as to how Sesame oil functions as a pain reliever: Mechanistic insights into how Sesame oil-derived compounds function as pain medications: A pharmaceutical mixture encompassing Sesamin and Sesamol (SAS), derived from Sesame seed or oil,  increases the expression of PD-L1, decreases the expression of Cox-2, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 17/June/2019, 12.58 pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
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June 17, 2019
Published by admin_auro at June 17, 2019
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Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing a pharmacological formulation encompassing Metformin, Navitoclax/ABT-263, & Dasatinib (MND) and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as BIRC5, p12DOC1, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 17/June/2019, 6.14 am

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that:  Probiotic-based chemotherapy targeting cancer stem […]
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June 17, 2019
Published by admin_auro at June 17, 2019
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Regenerative therapy for improving cognitive deficits in aged individuals: Chitosan, isolated from Shrimps and others, decreases vascular cell adhesion molecule 1 (VCAM 1), inhibits microglia activity, increases hippocampal neural precursor activity, ameliorates cognition, & attenuates age-related neurodegeneration, through up regulation of its target genes, 17/June/2019, 6.05 am

Introduction: What they say A study from the Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA, VA Palo Alto Health […]
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June 17, 2019
Published by admin_auro at June 17, 2019
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Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in chronic lymphocytic leukemia (CLL) and advanced metastatic cancers: A pharmaceutical mixture encompassing Venetoclax and Ibrutinib (VAI) and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as SMARCA4, KIBRA, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance and prolongs survival, and stalls CLL progression, via up-regulation of its target gene, 17/June/2019, 5.48 am

Introduction: What they say A study from the University of Texas M.D. Anderson Cancer Center, Houston, USA shows that “Ibrutinib and Venetoclax for First-Line Treatment of CLL.” This research […]
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June 14, 2019
Published by admin_auro at June 14, 2019
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Sesame oil-derived compounds functions as a longevity promoter: Sesamin or Sesamol, derived from sesame oil or seeds, slows down cardiac aging, and increases lifespan, via up-regulation of BubR1 and others genes, 14/June/2019, 10.25 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, USA; […]
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June 14, 2019
Published by admin_auro at June 14, 2019
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Natural product-based regenerative therapy for improving cognitive deficits in aged individuals: Sulforaphane, isolated from Broccoli and others, decreases vascular cell adhesion molecule 1 (VCAM 1), inhibits microglia activity, increases hippocampal neural precursor activity, ameliorates cognition, & attenuates age-related neurodegeneration, through up regulation of its target genes, 14/June/2019, 6.31 am

Introduction: What they say A study from the Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA, VA Palo Alto Health […]
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June 13, 2019
Published by admin_auro at June 13, 2019
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Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in chronic lymphocytic leukemia (CLL) and advanced metastatic cancers: A pharmaceutical mixture encompassing Venetoclax and Ibrutinib (VAI) and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as BIRC5, PIAS3, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance and prolongs survival, and stalls CLL progression, via up-regulation of its target gene, 13/June/2019, 10.26 pm

Introduction: What they say A study from the University of Texas M.D. Anderson Cancer Center, Houston, USA shows that “Ibrutinib and Venetoclax for First-Line Treatment of CLL.” This research […]
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June 12, 2019
Published by admin_auro at June 12, 2019
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Hydrogen sulphide (H2S)-based curative therapy for autoimmune diabetes (TIDM):  Hydrogen sulphide (H2S)  increases the expression of PD-L1, decreases the expression of TXNIP, augments Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 13/June/2019, 12.54 am

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical […]
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June 10, 2019
Published by admin_auro at June 10, 2019
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A coconut way to say no to weight gain and Diabetes: Coconut oil-derived compound Lauric acid plays a significant role in body weight control, energy homeostasis and TIIDM: Lauric acid (LA-C12) or Dodecanoic acid (DA), one of the main components (48-52%) of coconut oil,  decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 10/June/2019, 11.14 pm

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by […]
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June 9, 2019
Published by admin_auro at June 9, 2019
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A long myth that how coconut oil lowers cholesterol and triglyceride and increases HDL levels is explained: Lauric acid-based therapy for Non-alcoholic fatty liver disease (NAFLD):Lauric acid (C12) or Dodecanoic acid, one of the main components of  coconut oil, promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down-regulation of its target gene, 9/June/2018, 11.17 pm

The significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 […]
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June 9, 2019
Published by admin_auro at June 9, 2019
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Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in chronic lymphocytic leukemia (CLL) and advanced metastatic cancers: A pharmaceutical mixture encompassing Venetoclax and Ibrutinib (VAI) and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as TIMP3, PTPN14, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance and prolongs survival, and stalls CLL progression, via up-regulation of its target gene, 09/June/2019, 6.23 pm

Introduction: What they say A study from the University of Texas M.D. Anderson Cancer Center, Houston, USA shows that “Ibrutinib and Venetoclax for First-Line Treatment of CLL.” This research […]
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Ideas can even be life changing.

We generate bio-medical/pharma/therapeutic/clinical ideas for the scientific community. Good Ideas are uncommon and unique. This is because everyone’s educational background is different. As a result, every one’s thinking process is different. Consequently, his/her ability to connect/understand complex biological/pathological mechanism differs.

Dr L. Boominathan Ph.D.

President & Director-cum-Chief scientist

Dr Boominathan was the first one in the world to propose a p73/p63-dependent cancer suppressor pathway (Supported by a legally valid Invention disclosure document certified by an advocate-2002/3)

Dr Boominathan’s quote on Science

Science is not about how to follow the conventions, but about how not to follow the conventions

 
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