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April 18, 2019

An aspirin a day keeps metastatic cancer away, if so, what is the mechanism?: Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing Aspirin, a nonsteroidal anti-inflammatory drug, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as  E-cadherin, PDCD4, BIRC5,  p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 18/April/2019, 10.41 pm

What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that: An aspirin a day keeps metastatic […]
April 18, 2019

Intracardiac injection of Synthetic PreImplantation Factor (sPIF) promotes heart regeneration and repair: Intracardiac injection of Synthetic PreImplantation Factor (sPIF) decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up-regulation of its target gene, 18/April/2019, 8.01 am

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory […]
April 18, 2019

The anti-diabetic drug Canagliflozin protects against Myocardial Infarction and its associated complications: Canagliflozin (brand name: Invokana and Sulisent), a sodium -glucose co-transporter-2 inhibitor used in the treatment of TIIDM, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 18/April/2019, 6.50am

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of […]
April 17, 2019

A derivative of male hormone Dihydrotestosterone (DHT)  boosts longevity: Dihydrotestosterone (DHT) slows down cardiac aging, and increases lifespan, via up-regulation of BubR1 and others genes, 17/April/2019, 11.28 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, USA; […]
April 16, 2019

Embryo-derived peptide functions as a stroke medicine: Synthetic PreImplantation factor (sPIF) attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up-regulation of its target genes BDNF and NAMPT, 16/April/2019, 11.29 pm

Introduction: What they say  A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; […]
April 16, 2019

Mechanistic insights into how Bariatric surgery functions as a curative therapy for Diabetes Mellitus: Bariatric surgery  augments the expression of FGF19 and FGF1,  attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM, via upregulation of its target gene, 16/April/2019, 11.19 pm

Introduction: What they say  A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection […]
April 16, 2019

Ribonucleic acid-based therapy for diabetes (TIDM): LncRNA  H19 increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 16/April/2019, 11.08 pm

Introduction: What they say A study from the Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, […]
April 16, 2019

Embryo-derived peptide as a longevity-promoting agent: PreImplantation Factor (PIF)-based therapy for aging-associated diseases and Lifespan extension: Synthetic PreImplantation Factor (sPIF)  inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 16/April/2019, 11.01 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
April 16, 2019

Alleviating Diabetes with Bariatric surgery: Bariatric surgery increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 16/April/2019, 10.52 pm

Introduction: What they say A study from the Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, […]
April 15, 2019

Ribonucleic acid-based therapy for diabetes (TIDM): LncRNA PRLB increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 15/April/2019, 10.25 pm

Introduction: What they say A study from the Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, […]
April 15, 2019

Blood as an anti-diabetic medicine: Autologous blood transfusion-based therapy for TIIDM and obesity-associated metabolic deficits: Autologous blood transfusion increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM, via down-regulation of its target gene, 15/April/2018, 8.38 pm

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent […]
April 15, 2019

Oats as an Immune booster: Oats-based immune enhancement therapy: Avenanthramide C, found in Oats, increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 15/April/2019, 8.01 pm

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in […]

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