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 Total no of Ideas: 11670 
March 9, 2020

Curing, preventing and reversing diabetes with a commonly available antiasthmatic drug Montelukast: Montelukast-based therapy for TIIDM and obesity-associated metabolic deficits: Montelukast (trade name: Singulair and others), a vasodilator used in the treatment of asthma, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, decreases TXNIP expression, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM, via down-regulation of its target gene, 9/March/2020, 11.08 pm

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent […]
March 1, 2020

Repurposing the anti-allergic drug into a cardioprotective drug: Tranilast-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Tranilast, an anti-allergy drug increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 1/March/2020, 5.43 pm

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]
February 28, 2020

Mechanistic insights into how Vitamin C/Ascorbic acid enhances immunity against bacterial infections: Ascorbic acid-based immune enhancement therapy: Ascorbic acid increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 28/February/2020, 10.27 am

National Science day special ********* We wish everyone a very happy national science day. On this special occasion, we are happy to announce that Bio-Med/Pharma/Therapeutic/Clinical ideas posted […]
February 28, 2020

Repurposing the anti-hypertensive agent into an anti-malarial agent: Nifidipine, a calcium channel blocker, increases Ferroportin expression, decreases intracellular iron accumulation, inhibits cellular damage, prevents hemolysis, and inhibits malaria infection, via upregulation of its target gene, 28/February/2020, 9.39 am

National Science day special ********* We wish everyone a very happy national science day. On this special occasion, we are happy to announce that Bio-Med/Pharma/Therapeutic/Clinical ideas posted […]
February 26, 2020

Repurposing the anti-asthmatic agent Tranilast into an anti-HIV agent: Tranilast (trade name: Rizaben and others) increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 26/February/2020, 11.07 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Repurposing the anti-asthmatic agent Tranilast into an anti-HIV agent: Tranilast (trade name: Rizaben […]
February 24, 2020

Molecular therapy for body weight control, energy homeostasis and TIIDM: TICAM1/TRIF[Toll-like receptor adaptor molecule1/TIR-domain-containing adapter-inducing interferon-beta] decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 24/February/2020, 11.12 pm

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by […]
February 22, 2020

Repurposing the anti-hypertensive agent Carvedilol into an anti-HIV agent: Carvedilol (trade name: Coreg and others)) increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 22/February/2020, 11.19 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Repurposing the anti-hypertensive agent Carvedilol into an anti-HIV agent: Carvedilol (trade name: Coreg […]
February 20, 2020

Mechanistic insights into how Blue zone longevity diet protects against cardiac dysfunction: Having honey on a daily basis will protect you against cardiac dysfunction and extend lifespan:Chrysin, found in propolis and honey, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 20/February/2020, 8.10 pm

Idea Proposed/Formulated by: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD. From research findings to Therapeutic opportunity:  Blue zone longevity diet, consumed by long-lived people from blue […]
February 20, 2020

Repurposing the anti-lipidemic agent Fenofibrate into an anti-HIV agent: Fenofibrate  (trade name: Fenoglide, Lipofen, Tricor and others)), an antilipidemic drug, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 20/February/2020, 9.39 am

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Repurposing the anti-lipidemic agent Fenofibrate into an anti-HIV agent: Fenofibrate  (trade name: Fenoglide, Lipofen, […]
January 26, 2020

Taurine-based regenerative therapy for curing Glaucoma: Taurine/2-Aminoethane-1-sulfonic acid increases the expression of genes that promote regeneration,  promotes reprogramming of aged eye cells, increases telomerase expression, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against and reverses glaucoma,  via upregulation of its target gene, 26/January/2019, 11.46 pm

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, […]
January 20, 2020

Mechanistic insights into how Okinawan longevity diet protects against cardiac dysfunction: Having turmeric tea on a daily basis will protect you against cardiac dysfunction and extend lifespan: Curcumin (Diferuloylmethane), found in turmeric, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 20/January/2020, 11.54 pm

Idea Proposed/Formulated by: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD. From research findings to Therapeutic opportunity:  Okinawan longevity diet, consumed by long-lived people from an island […]
January 18, 2020

 Lifespan extension therapy comes of age: Metfomin aids in Lifespan extension: Metformin, the widely prescribed drug in the treatment of type II diabetes, activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, increases adult stem cell proliferation, alleviates ageing feature and extends lifespan, via upregulation of its target genes ATG5 (Autophagy-related 5) and telomerase, 18/January/2020, 11.59 pm

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was […]

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Dr Boominathan’s quote on Science

Science is not about how to follow the conventions, but about how not to follow the conventions