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 Total no of Ideas: 11581 
July 30, 2019
Published by admin_auro at July 30, 2019
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Probiotics as biological drugs: Repurposing the Probiotic Verrucomicrobia Akkermansia Muciniphila into a longevity/healthspan-promoting bio-drug:  Probiotic Verrucomicrobia Akkermansia Muciniphila inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 30/July/2019, 8.39 am

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
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July 29, 2019
Published by admin_auro at July 29, 2019
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Solving a seventy plus year puzzle as to how labor pain relief medication Pethidine functions as a pain reliever: Mechanistic insights into how Pethidine  functions as an analgesic agent: Pethidine (trade name: Meperidine/Demerol), used to decrease feeling in a specific area of the body, in post-operative pain management, in the treatment of lower back pain and in others,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 29/July/2019, 2.48 pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
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July 24, 2019
Published by admin_auro at July 24, 2019
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Solving a sixty plus year puzzle as to how Bupivacaine functions as a pain reliever: Mechanistic insights into how Bupivacaine functions as a local anesthetic agent: Bupivacaine  (trade name: Marcaine, Sensorcaine, Vivacaine, others ), used to decrease feeling in a specific area of the body, in post-operative pain management, in the treatment of lower back pain and in others,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 24/July/2019, 6.34 am

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
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July 23, 2019
Published by admin_auro at July 23, 2019
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Probiotic-based therapy for aging-associated diseases and Lifespan extension: A therapeutic mix encompassing Probiotic Bifidobacterium LKM512 and Arginine inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 23/July/2019, 8.03 am

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
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July 21, 2019
Published by admin_auro at July 21, 2019
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Solving a sixty-year old puzzle as to how Amitriptyline functions as a pain reliever: Mechanistic insights into how Amitriptyline functions as a pain medication: Amitriptyline (trade name: Elatrol, Elatrolet, Elavil, Endep, Fiorda, Laroxyl, Latilin, Levate and others), used in the treatment for major depressive order, and anxiety disorders, prevention of migraines, fibromyalgia, postherpetic neuralgia, and insomnia,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 12/July/2019, 11.29 pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
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July 19, 2019
Published by admin_auro at July 19, 2019
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Thymol-based regenerative therapy for improving cognitive deficits in the aged individuals: Thymol, isolated from Trachyspermum Ammi/Ajwain seeds and oil,  decreases vascular cell adhesion molecule 1 (VCAM 1), inhibits microglia activity, increases hippocampal neural precursor activity, ameliorates cognition, & attenuates age-related neurodegeneration, through up regulation of its target genes, 19/July/2019, 9.29 pm

Introduction: What they say A study from the Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA, VA Palo Alto Health […]
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July 18, 2019
Published by admin_auro at July 18, 2019
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Natural product-derived Analgesics:  Mechanistic insights into how natural product-derived Manassantin B  functions as a pain medication: Manassantin B, isolated from Saururus chinensis (also known as Asian lizard’s tail), increases the expression of PD-L1, TRPV1, and CGPR, decreases the expression of Cox-2, attenuates acutes and chronic pain, headache, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 17/July/2019, 10.23 am

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
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July 17, 2019
Published by admin_auro at July 17, 2019
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Natural product-based Lifespan extension therapy:  Diosgenin, derived from Dioscorea,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 17/July/2019, 11.10 pm

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
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July 17, 2019
Published by admin_auro at July 17, 2019
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Where eating the peel will protect you against viral diseases than the pulp (fruit): Citrus peel-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Hesperidin, Tangeretin & Nobiletin (HTN), isolated from citrus flavonoid purity mixture or citrus peels, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via upregulation of its target gene, 17/July/2019, 10.40 pm

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex […]
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July 17, 2019
Published by admin_auro at July 17, 2019
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Probiotics as Longevity-promoters: The tiny probiotic may increase the lifespan of mighty humans: Probiotic-based therapy for aging-associated diseases and Lifespan extension: Probiotic Bifidobacterium animalis subsp.lactis LKM512 inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 17/July/2019, 10.10 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
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July 17, 2019
Published by admin_auro at July 17, 2019
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Probiotics as Analgesics: Probiotic bifidobacterium animalis subsp. lactus LKM512  functions as a pain reliever: Mechanistic insights into how Probiotic bifidobacterium animalis subsp. lactus LKM512  functions as a pain medication: Probiotic bifidobacterium animalis subsp. lactus LKM512  increases the expression of PD-L1, TRPV1, and CGPR, decreases the expression of Cox-2, attenuates acutes and chronic pain, headache, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 17/July/2019, 11.51 am

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
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July 15, 2019
Published by admin_auro at July 15, 2019
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Surgery to mitigate complications of diabetes and obesity comes of age: Mechanistic insights into how Roux-en-Y gastric bypass (RYGB) surgery can save you from blood sugar disease (Diabetes Mellitus): Roux-en-Y gastric bypass (RYGB), one of the bariatric surgical procedure performed for weight loss,  augments the expression of FGF19 and FGF1,  attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM, via upregulation of its target gene, 15/July/2019, 7.41 am

Introduction: What they say  A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection […]
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Dr Boominathan was the first one in the world to propose a p73/p63-dependent cancer suppressor pathway (Supported by a legally valid Invention disclosure document certified by an advocate-2002/3)

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Science is not about how to follow the conventions, but about how not to follow the conventions

 
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