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 Total no of Ideas: 11648 
December 24, 2019
Published by admin_auro at December 24, 2019
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Ascorbic acid-based regenerative cardiovascular therapy: Molecular mechanistic insight into how Vitamin C/Ascorbic acid protects against and promotes functional recovery after Myocardial Infarction:  Vitamin C/Ascorbic acid(AA)  inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte proliferation, regeneration and survival after myocardial infarction, via up-regulation of its target gene, 24/December/2019, 11.55 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of […]
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December 20, 2019
Published by admin_auro at December 20, 2019
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A cup of Chamomile tea everyday may extend your lifespan:  Apigenin-based anti-ageing and Lifespan extension therapy:  Apigenin (4′,5,7-trihydroxyflavone), the main constituent of Chamomile tea and others, increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels, increases telomerase levels, and enhances lifespan, via up regulation of its target gene, 20/December/2019, 12.47 pm

Introduction: What they say  A study from Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str.  Bonn, Germany; and Institute for Genetics and CECAD Research Center, […]
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December 17, 2019
Published by admin_auro at December 17, 2019
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Sauna (heat/thermal) therapy may safeguard your heart against cardiac dysfunction: Sauna (heat/thermal) therapy for cardiomyocyte proliferation and heart regeneration: Sauna (heat/thermal) therapy (at 41°C for 20 minutes) decreases tumor suppressor Mir-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up-regulation of its target gene, 17/December/2019, 7.14 am

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory […]
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December 11, 2019
Published by admin_auro at December 11, 2019
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Mechanistic insights into Okinawan longevity diet: Consuming ample amounts of Sweet potatoes will extend your lifespan: Sweet potato-derived compounds function as longevity promoters: ß-carotene, derived from sweet potatoes, may  increase insulin sensitivity, slow down cardiac aging, increase regeneration of tissues, and increase lifespan, via up-regulation of BubR1 and others genes, 11/December/2019, 6.58 am

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, USA; […]
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December 6, 2019
Published by admin_auro at December 6, 2019
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Apigenin/Luteolin-based regenerative therapy for curing Glaucoma: A pharmaceutical mixture encompassing Apigenin and Luteolin increases the expression of genes that promote regeneration,  promotes reprogramming of aged eye cells, increases telomerase expression, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against and reverses glaucoma,  via upregulation of its target gene, 6/December/2019, 5.40 am

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, […]
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December 3, 2019
Published by admin_auro at December 3, 2019
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Vitamin-E based therapy for pain management: Mechanistic insights into how VitmainE isoform γ-tocotrienol (γT3) functions as an analgesic agent: γ-tocotrienol (γT3) increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 3/November/2019, 9.29 am

Introduction: What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for […]
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December 1, 2019
Published by admin_auro at December 1, 2019
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Lithium-based regenerative therapy for curing Glaucoma: Repurposing the antipsychotic drug Lithium into an anti-glaucoma agent: Lithium, used in the treatment of bipolar disorder & depression, increases the expression of genes that promote regeneration,  promotes reprogramming of aged eye cells, increases telomerase expression, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against and reverses glaucoma,  via up regulation of its target gene, 1/December/2019, 11.56 pm

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, […]
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November 29, 2019
Published by admin_auro at November 29, 2019
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Treating advanced cancers resistant to Paclitaxel/Topotecan/Temozolomide: Probiotic-based Chemotherapy (PCT) targeting cancer stem cells and immune-inhibitory receptors in advanced ovarian cancer and in other advanced metastatic cancers resistant to Paclitaxel/Topotecan/Temozolomide: A pharmaceutical mixture encompassing Veliparib (ABT-888) and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as BTG2, BIRC5, p53, and TA-p73/p63, INK4a and others, decreases PP2A expression, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance mediated by Paclitaxel/Topotecan/Temozolomide, and stalls advanced ovarian cancers  progression, and prolongs survival, via up-regulation of its target gene, 29/November/2019, 4.20 pm

Introduction: What they say A study from the Department of Gynecologic Oncology and Reproductive Medicine,  University of Texas M.D. Anderson Cancer Center, 1155 Pressler Dr., Houston, TX 77030, […]
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November 14, 2019
Published by admin_auro at November 14, 2019
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Curing, preventing and reversing diabetes with a commonly available blood pressure drug Hydralazine: Hydralazine-based therapy for TIIDM and obesity-associated metabolic deficits: Hydralazine (trade name: Apresoline, BiDil, and others), a vasodilator used in the treatment of high blood pressure,  cardiac failure and others, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, decreases TXNIP expression, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM, via down-regulation of its target gene, 14/November/2019, 9.58 am

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent […]
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November 8, 2019
Published by admin_auro at November 8, 2019
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Treating advanced cancers resistant to Herceptin and Lapatinib: Probiotic-based Chemotherapy (PCT) targeting cancer stem cells and immune-inhibitory receptors in advanced breast cancers and in other advanced metastatic cancers resistant to Herceptin and Lapatinib: A pharmaceutical mixture encompassing Dacomitinib  (Trade name: Vizimpro, and PF-00299804)  and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as PIAS3, VHL, p53, and TA-p73/p63, INK4a and others, decreases PP2A and Her2 expression, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance mediated by Herceptin and Lapatinib, and stalls advanced breast cancers  progression, and prolongs survival, via up-regulation of its target gene, 8/November/2019, 6.39 pm

Introduction: What they say A study from the Department of Medicine, Division of Hematology/Oncology, Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, […]
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November 7, 2019
Published by admin_auro at November 7, 2019
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Treating advanced cancers resistant to Paclitaxel/Topotecan/Temozolomide: Probiotic-based Chemotherapy (PCT) targeting cancer stem cells and immune-inhibitory receptors in advanced ovarian cancers and in other advanced metastatic cancers resistant to Paclitaxel/Topotecan/Temozolomide: A pharmaceutical mixture encompassing Veliparib (ABT-888) and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as TPM1, CADM1/2,  p53, and TA-p73/p63, INK4a and others, decreases PP2A expression, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance mediated by Paclitaxel/Topotecan/Temozolomide, and stalls advanced ovarian cancers  progression, and prolongs survival, via up-regulation of its target gene, 7/November/2019, 11.59 pm

Introduction: What they say A study from the Department of Gynecologic Oncology and Reproductive Medicine,  University of Texas M.D. Anderson Cancer Center, 1155 Pressler Dr., Houston, TX 77030, […]
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November 4, 2019
Published by admin_auro at November 4, 2019
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Curing, preventing, and reversing autoimmune diabetes  (TIDM) with Tellurium Compounds: Ammonium trichloro(dioxoethylene-o,o’)tellurate (AS101), an immunomodulator, increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up-regulation of its target gene, 4/November/2019, 12.10 pm

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and […]
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Ideas can even be life changing.

We generate bio-medical/pharma/therapeutic/clinical ideas for the scientific community. Good Ideas are uncommon and unique. This is because everyone’s educational background is different. As a result, every one’s thinking process is different. Consequently, his/her ability to connect/understand complex biological/pathological mechanism differs.

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Dr Boominathan was the first one in the world to propose a p73/p63-dependent cancer suppressor pathway (Supported by a legally valid Invention disclosure document certified by an advocate-2002/3)

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Science is not about how to follow the conventions, but about how not to follow the conventions

 
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