A study from Section on Integrative Physiology-Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA. has reported that “Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy.“
This study was published in the June 1, 2014 Journal of Clinical Investigation (JCI) [I.F >15] by Prof. C. Ronald Kahn, Mori MM and others from Integrative Physiology-Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA “
On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Therapeutic insights into the regulation of brown/white adipocyte determination: Tumor suppressor miRNA Let-7 promotes lipodystrophy via down regulation of its target gene. This study may suggest that Let-7, by down regulating its target gene, it may promote insulin resistance and lipodystrophy. Together, this study suggests that pharmacological formulations encompassing “AntagomiR-Let-7 or Let-7 suppressors” can be used in the treatment of lipodystrophy and insulin resistance.
Idea Proposed/Formulated by: Dr L Boominathan PhD
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Citation: Boominathan, Therapeutic insights into the regulation of brown/white adipocyte determination: Tumor suppressor miRNA Let-7 promotes lipodystrophy via down regulation of its target gene, 16/July/2014, 8.19 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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