On the eve of Mahatma Gandhi Birth Anniversary
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We wish everyone a happy Mahatma Gandhi Jayanti 2014. On this special occasion, we are happy to announce that Ideas posted today (02/October/2014) will be available to the use of Scientists/Professors/Physicians/Researchers for free. So, there will be no terms and conditions for the ideas posted today (02/October/2014). Each idea posted will be served first come, first served basis. For more details, you may write to us at info@genomediscovery.org
Dr L Boominathan PhD
CEO & CSO, GBMD
A study from the School of Life Sciences, Tsinghua University, Beijing 100084, China shows that “Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility.”
This study was published in the 7 January issue of 2014 Proc Natl Acad Sci U S A (I.F: >10) by Prof Huang L, Wang Z and others from Tsinghua University, Beijing 100084, China.
On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Natural product-based therapy for Mammary Cancer: Triptolide, a natural compound found in the herb Thunder of God vine, suppresses Mammary cancer cell migration and invasion via down regulation of Receptor for hyaluronan-mediated motility (RHAMM)/Hyaluronan-mediated motility receptor (HMMR). This study may suggest that Triptolide, by down regulating its target gene, it may inhibit the expression of RHAMM/HMMR. Together, this study suggests that pharmacological formulations encompassing “Triptolide or its analogues“ can be used to inhibit cancer metastasis and invasion.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Citation: Boominathan, Natural product-based therapy for Mammary Cancer: Triptolide, a natural compound found in the herb Thunder of God vine, suppresses Mammary cancer cell migration and invasion via down regulation of Receptor for hyaluronan-mediated motility (RHAMM)/Hyaluronan-mediated motility receptor (HMMR), 02/October/2014, 12.34 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Web: http://genomediscovery.org
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Significance: This study suggests that Triptolide, by decreasing the expression of RHAMM/HMMR, it may (1) inhibit Mammary cancer cell migration and invasion (MCCMI); and (2) serve as an anti-metastatic agent.