A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Natural product Life-extension therapy: Calycosin, isolated from the root of Astragalus membranaceous, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via upregulation of its target gene
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Calycosin, isolated from the root of Astragalus membranaceous, may promote longevity via down regulation of p70S6 Kinase
Significance: This study suggests a natural product-based life extension therapy. Calycosin, by increasing the expression of its target gene, it may decrease the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase). Thereby, it may promote (1) resistance to bone, immune, and motor dysfunction; and (2) insulin sensitivity.
Calycosin
Thus, pharmacological formulations encompassing “
Calycosin or it analogues“ can be used to extend the lifespan of an individual.
Citation: Boominathan, Natural product Life-extension therapy: Calycosin, isolated from the root of Astragalus membranaceous, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 04/October/2016, 7.57 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Web: http://genomediscovery.org or http://newbioideas.com
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Undisclosed information: How does Calycosin decrease the expression of p70S6 Kinase?
# Research cooperation