A study from the Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA shows that: “Curcumin suppresses NTHi-induced CXCL5 expression via inhibition of positive IKKß pathway and up-regulation of negative MKP-1 pathway.” This study was published in the 19 August 2016 issue of the journal “Scientific reports” by Prof. Li JD, Konduru and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for Otitis Media: Neem leaf extract induces MKP-1 expression, inhibits IKKß phosphorylation, suppresses NDHi-induced inflammatory mediator C-X-C motif chemokine ligand 5 (CXCL5) expression, controls overreactive inflammatory responses, inhibits the progression of Otitis media and ameliorates conductive hearing loss via up-regulation of its target gene
Significance:
Given that: (1) Ottis media is an infection/inflammation of middle ear, with debilitating consequences of conductive hearing loss; (2) molecular mechanisms involved in the development of middle ear inflammatory diseases is poorly understood; (3) drugs that are currently used to treat inflammatory disease of ear are ineffective; (4) Ottis media affects about 16% of people (about 740 million) each year and it is more common amoung children. (5) nearly 141 million people have hearing loss due to ottis media globally each year; (6) Nontypeable Haemophilus influenzae (NTHi) is the major bacterial pathogen that causes Ottis media; (7) NTHi that causes middle ear infections become resistant to conventional antibiotic therapy frequently; (8) prolonged use of immunosuppressant drugs is detrimental to the health of childrens; and (9) millions of dollars are being spent every year worldwide to treat the infections/inflammation of ear, there is an urgent need to find: (i) a way to control abnormal levels of inflammatory mediators found in ottis media patients; (ii) non-antibiotic/steroidic therapeutics; (iii) a side-effect-free natural product-based drug; and (iv) a way to effectively treat and cure Ottis media.
Prof. Li’s research team has recently shown that Curcumin, by suppressing the expression of CXCL5, it inhibits NTH-1-induced Ottis media.
This study suggests an yet another natural product-based compound for the treatment of Ottis media.
Figure 1 Neem leaf extract inhibits the progression of NDHi-aggravated middle ear infection via up-regulation of MKP1/DUSP-1 and down-regulation of CXCL5.
This study suggests, for the first time, that Neem leaf extract, by increasing the expression of its target gene, it may: (1) increase the expression of MKP/DUSP1; (2) inhibit IKKß phosphorylation; (3) suppress NDHi-induced inflammatory mediator C-X-C motif chemokine ligand 5 (CXCL5) expression; and (4) control overreactive inflammatory responses. Thereby, it may: (1) inhibit the progression of Otitis media; and (2) ameliorate conductive hearing loss. Thus, pharmacological formulations encompassing “Neem leaf extract or an active compound isolated from it, including Oleanolic acid” may be used to treat Ottis media.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed information: How Neem leaf extract increases the expression of MKP1/DUSP-1
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Citation: Natural product therapy for Otitis Media: Neem leaf extract induces MKP-1 expression, inhibits IKKß phosphorylation, suppresses NDHi-induced inflammatory mediator C-X-C motif chemokine ligand 5 (CXCL5) expression, controls overreactive inflammatory responses, inhibits the progression of Otitis media and ameliorates conductive hearing loss via up regulation of its target gene, 11/October/2016, 9.20 pm