A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for Myocardial Infarction: Avicularin, a bio-active flavonol isolated from Polygonum aviculare, Rhododendron aureum and Taxillus kaempferi, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10)
Significance:
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; and (3) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free drug.
This study suggests a natural product-based cardiac regeneration therapy. Avicularin, by increasing the expression of its target gene, it may increase the expression of PNUTS/PPP1R10. Thereby, it may: (1) inhibit DNA damage responses, (2) inhibit telomere shortening; and (3) promote cardiomyocyte survival/regeneration.
Avicularin, found in Taxillus kaempferi, promotes myocardial survival and prevents myocardial infarction via up-regulation of PNUTS//PPP1R10
Thus, by treating myocardial patients with avicularin, one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests that pharmacological
Avicularin
Avicularin is also found in Rhododendron aureum
formulations encompassing “Avicularin or its analogues may be used to improve cardiac
Avicularin is also found in Polygonum aviculare
function after myocardial infarction.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Web:http://genomediscovery.org or http://newbioideas.com
To cite: Boominathan, Natural product therapy for Myocardial Infarction: Avicularin, a bio-active flavonol isolated from Polygonum aviculare, Rhododendron aureum and Taxillus kaempferi, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 16/October/2016, 7.38 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Avicularin increases the expression of PNUTS/PPP1R10
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