What they say: Introduction:
The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech and his research team from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.” This study provides mechanistic insights into how TPP1 regulates telomerase function.
What we say:
In connection with the finding presented above, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Natural product Anti-telomerase cancer therapy: Eriocitrin, a flavonoid commonly found in lemons, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and telomerase and inhibits cancer progression via down-regulation of its target gene,
Significance:
Given that cancer causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a cheaper alternative to the existing expensive drugs; (ii) a side-effect-free natural product-based drug; (iii) a way to effectively treat cancers that are resistant to anti-cancer drugs; and (iv) a way to effectively treat and eradicate metastatic progression of cancer.
From Research Findings to Therapeutic opportunity:
Eriocitrin, by decreasing the expression of its target gene, it may suppress the expression of Tripeptidyl Peptidase 1 (TPP1). Remarkably, over 90% human tumors overexpress cellular immortality gene telomerase, suggesting that inhibition of its activity may increase the efficacy of anticancer therapy.
Lemon tree
Figure 1. Lemon fruits. Eriocitrin, found in lemons, inhibits human cancer cell proliferation via down-regulation of Tripeptidyl Peptidase 1 (TPP1) and telomerase
Eriocitrin
Together, this study suggests that pharmacological formulations encompassing “Eriocitrin or its analogs“ may be used to treat human cancers.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Citation: Boominathan, L., Natural product Anti-telomerase cancer therapy: Eriocitrin, a flavonoid commonly found in lemons, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and telomerase and inhibits cancer progression via down-regulation of its target gene, 12/November/2016, 7.10 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed mechanistic insights: How does Eriocitrin suppress the expression of Tripeptidyl Peptidase 1 (TPP1) and telomerase?
# Research cooperation