Introduction: What they say:
The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.” This study provides mechanistic insights into how TPP1 regulates telomerase function.
What we say:
In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Anti-telomerase cancer therapy: NKD1 (Naked cuticle 1) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene
Significance:
Given that: (1) over 90% human tumors overexpress immortality gene telomerase; (2) cancer causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a way to inhibit telomerase activity in human tumors, to increase the efficacy of anticancer therapy; (ii) a cheaper alternative to the existing expensive drugs; (iii) a side-effect-free natural product-based drug; (iv) a way to effectively treat cancers that are resistant to anti-cancer drugs; and (v) a way to effectively treat and eradicate metastatic progression of cancer.
From Research Findings to Therapeutic opportunity:
NKD1 (Naked cuticle 1) has earlier been shown to function as a negative regulator of Wnt signalling pathway. This study suggests that NKD1, by increasing the expression of its target gene, it may suppress the expression of Tripeptidyl Peptidase 1 (TPP1). Remarkably, over 90% of the human tumors overexpress the cellular immortality gene telomerase, suggesting that inhibition of its activity may increase the efficacy of anticancer therapy. Taken together, pharmacological formulations encompassing “NKD1 (Naked cuticle 1) or its activators“ may be used to treat human cancers that specifically overexpress the cellular immortality gene telomerase.
Details of the Research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $100#
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed information: How NKD1 (Naked cuticle 1) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and telomerase
# Research cooperation
References:
Citation: Boominathan, L., Anti-telomerase cancer therapy: MiRNA-149 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 22/November/2016, 7.53 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Courtesy: When you cite drop us a line at info@genomediscovery.org
Web: http://genomediscovery.org or http://newbioideas.com