Research findings to Therapeutic opportunity:
The study presented here suggests that Anticancer drug Campothecin (CPT), by increasing the expression of its target genes, it may decrease the expression of oncoprotein PDPN.
Thereby, it may inhibit proliferation, migration, invasion, and metastasis of cancer cells. Thus, Campothecin (CPT) may be used to target tumors that specifically overexpress PDPN.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Undisclosed information: How Campothecin (CPT) decreases the expression of metastasis suppressor PDPN
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References:
Citation: Boominathan, L., Anti-metastasis therapy: Anticancer drug Campothecin (CPT) decreases PDPN expression, invasion, migration and metastasis of tumor cells via up regulation of its target gene, 28/November/2016, 6.55 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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