What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived Lifespan extension therapy: Persimmon tannin fruit extract increases life span via up-regulation of its target gene BubR1
What is known?
I have recently published that Persimmon tannin fruit extract: (1) increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes; and (2) increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function
From Research Findings to Therapeutic Opportunity:
This study suggests a natural product-based life extension therapy. Persimmon tannin fruit extract, by decreasing the expression of its target gene, it may increase the expression of BuBR1.
[easy_payment currency=”USD”]
Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing “Persimmon tannin extract or an active compound isolated from it” may be used to extend the lifespan of an individual.
Figure 1.Persimmon Tannin may promote mammalian life span via up regulation of BuBR1
Figure 2. Persimmon tannin fruits may function as longevity promoters
Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $100#
Undisclosed mechanistic information: How Persimmon tannin fruit extract increases the expression of BubR1 and extends mammalian life-span
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# Research cooperation
References:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Natural product-derived Lifespan extension therapy: Persimmon tannin fruit extract increases life span via up-regulation of its target gene BubR1, 10/December/2016, 7.41 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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