What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived Lifespan extension therapy: Saponin, found in Panax Japonicus and Soapworts among others, increases life span via up-regulation of its target gene BubR1
What is known?
I have recently published that Saponin may: (1) increase Spermidine levels, augment autophagy, mitophagy and mitochondrial respiration, lower systemic blood pressure, and protect from cardiac diseases; and (2) increase NMN levels, decrease age-associated weight gain, augment energy metabolism, improve physical activity and insulin sensitivity, promote healthy lipid profile, and improve eye function
From Research Findings to Therapeutic Opportunity:
This study suggests a natural product-based life extension therapy. Saponin, by increasing the expression of its target gene, it may increase the expression of BuBR1.
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Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing “Saponin or its analogues or Saponin in combination with any of the known anti-ageing drug“ may be used to extend the lifespan of an individual (figs. 1-3).
Figure1. Saponin, isolated from Panax japonicus and Soapwort among others, as indicated below, may promote mammalian life span via up regulation of BuBR1
Figure 2 Saponin. Image credit: Wikipedia
Figure 3. Soapwort.
Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $100#
Undisclosed mechanistic information: How Saponin increases the expression of BubR1 and extends mammalian life-span
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# Research cooperation
References:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Natural product-derived Lifespan extension therapy: Saponin, found in Panax Japonicus and Soapworts among others, increases life span via up-regulation of its target gene BubR1, 11/December/2016, 7.07 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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