Introduction: What they say:
A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of 24.973] by Drs. Zusen Fan, Xia and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product Immune enhancement therapy: Fisetin, isolated from Strawberry, blueberries, mangoes, apples, persimmon, kiwi, onions, grapes and cucumber among others, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene
From Research Findings to Therapeutic Opportunity:
This study suggests, for the first time, Fisetin, by increasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection.
Figure1. Fisetin, isolated from Strawberry, blueberries, mangoes, apples, persimmon, kiwi, onions, grapes and cucumber among others, promotes innate immunity against bacterial infection via up-regulation of Sox2
Figure2. Fisetin
Together, pharmacological formulations encompassing “Fisetin or its analogues or Fisetin in combination with any of the known compounds that are in use to enhance immunity” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance (fig.2).
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Amount: $100
Undisclosed mechanistic information: How Fisetin: (1) enhances innate immunity against bacterial infection; and (2) promotes bacterial resistance?
# Research cooperation
References:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Natural product Immune enhancement therapy: Fisetin, isolated from Strawberry, blueberries, mangoes, apples, persimmon, kiwi, onions, grapes and cucumber among others, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 14/December/2016, 8.57 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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