What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived Lifespan extension therapy: Theobromine, isolated from Theobroma and commonly found in Chocolates, increases life span via up-regulation of its target gene BubR1
What is known?
I have recently published that Theobromine may increase NMN levels, decrease age-associated weight gain, augment energy metabolism, improve physical activity and insulin sensitivity, promote healthy lipid profile, and improve eye function.
From Research Findings to Therapeutic Opportunity:
This study suggests a natural product-based life extension therapy. Theobromine, by increasing the expression of its target gene, it may increase the expression of BuBR1.
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Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing “Theobromine or its analogues or Theobromine in combination with any of the known anti-ageing drug“ may be used to extend the lifespan of an individual (figs. 1-3).
Figure 1. Theobroma. Theobromine, isolated from Theobroma, may promote mammalian life span via up regulation of BuBR1
Figure 2. Theobromine functions as a longevity promoter
Figure 3. Theobromine, found in Dark Chocolates.
Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $100#
Undisclosed mechanistic information: How Theobromine increases the expression of BubR1 and extends mammalian life-span
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# Research cooperation
References:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Natural product-derived Lifespan extension therapy: Theobromine, isolated from Theobroma and commonly found in chocolates, increases life span via up-regulation of its target gene BubR1, 14/December/2016, 10.50 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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