Introduction: What they say
Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.”
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Human Leukemias: Boehmenan, found in stem of Caulis clematidis armandii and Hibiscus ficulneus, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4
From Research findings to Therapeutic opportunity:
This study suggests that Boehmenan, by increasing the expression of its target gene, it may increase the expression of a number of tumor suppressor genes, including IRF4. Thereby, it could inhibit the progression of B-Cell and myeloid leukemias (figs. 1 -4).
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Taken together, this study suggests that pharmacological formulations encompassing “Boehmenan or its analogues or Boehmenan in combination with other anticancer drugs“ may be used to inhibit B-Cell and myeloid leukemias.
Figure 1. Boehmenan, found in stem of Caulis clematidis armandii and Hibiscus ficulneus, as indicated below, functions as an anti-cancer agent against human leukemias
Figure 2. Clematis armandii
Figure 3. Hibiscus ficulneus
Figure 4 Mechanistic insight into how Boehmenan increases the expression of IRF4 to prevent cancer progression
Details of the research details:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How Boehmenan increases the expression of IRF4?
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References:
Web: http://genomediscovery.org or newbioideas.com
Citation: Boominathan, L., Natural product-derived therapy for Human Leukemias: Boehmenan, found in stem of Caulis clematidis armandii and Hibiscus ficulneus, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 25/December/2016, 12.03 am, Genome-2-Bio-Medicine Discovery Center.
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