Introduction: What they say:
A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of 24.973] by Drs. Zusen Fan, Xia and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived Immune enhancement therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), a flavonoid glucoside found in Castor-aralia (kalopanax-pictus), Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene
From Research Findings to Therapeutic Opportunity:
This study suggests, for the first time, Methyl 3,5-dicaffeoyl quinate (MDQ), by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection.
Together, pharmacological formulations encompassing “Methyl 3,5-dicaffeoyl quinate (MDQ) or its analogues or Methyl 3,5-dicaffeoyl quinate (MDQ) in combination with other drugs” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance (figs. 1-4).
Figure 1. Castor-aralia (kalopanax-pictus). Methyl 3,5-dicaffeoyl quinate (MDQ), found in Castor-aralia (kalopanax-pictus) among others, as indicated below,. increase the expression of Sox2 and promote innate immunity against bacterial infection.
Figure 2. Salicornia herbacea L
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How Methyl 3,5-dicaffeoyl quinate (MDQ): (1) enhances innate immunity against bacterial infection; and (2) promotes bacterial resistance?
Amount: $100
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References:
Citation: Boominathan, L., Natural product-derived Immune enhancement therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), a flavonoid glucoside found in Castor-aralia (kalopanax-pictus), Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 20/January/2017, 10.27 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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