From Significance of the study to Public health relevance:
Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) most of the cancer patients die due to metastasis; (iv) cancer treatment causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) bio-molecules that drive metastatic process; and the the way to prevent their expression; (ii) a way to activate immune system to combat cancer (Cancer immunotherapy); (ii) a cheaper alternative to the existing expensive anticancer drugs; (ii) a side-effect-free natural product-based drug; (iii) increase the therapeutic index of anticancer drugs; and (iv) a way to effectively treat and prevent metastatic progression and relapse of advanced/drug-resistant cancers.
Research findings to Therapeutic opportunity:
A number of studies suggest that Piper betle leaf extract functions as an anticancer agent. However, the mechanism of action is far from clear.
This study suggests that Piper betle leaf extract, by increasing the expression of its target genes, it may decrease the expression of metastasis suppressor PMP22 (fig. 1).
Fig1. Mechanistic insights into how Piper betle leaf (PBL) functions as an anti-metastasis agent
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Thereby, it may inhibit migration, invasion and metastasis of cancer cells. Thus, pharmacological formulations encompassing “Piper betle leaf extract or an active compound isolated from it either alone or in combination with other anticancer drugs” may be used to inhibit the progression of invasive tumors.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $2
Undisclosed information: How Piper betle leaf extract decreases the expression of metastasis promoter PMP22
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# Research cooperation
References:
Citation: Boominathan, L., Molecular therapy for Metastatic cancers: Piper betle leaf extract decreases the expression of PPM22 and inhibits migration, invasion and metastasis of cancer cells via up regulation of its target gene, 5/March/2017, 10.29 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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