What they say: Introduction:
A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of Medicine, 522 First Avenue, New York, NY 10016, USA shows that Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice. This study was published in the 11 October 2016 issue of the Journal “Cell Reports” by Prof David J. Picketts, Dr. Matías Alvarez-Saavedra and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Swimming as a therapeutic exercise for brain repair and Lifespan extension: Swimming therapy increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene
From Research Findings to Therapeutic opportunity:
This study suggests a Swimming training-based therapy for brain repair and lifespan extension. Swimming training, by attenuating the expression of its target genes, it may increase the expression of VGF and BDNF (Brain Derived Neurotrophic Factor).
Figure 1. Swimming therapy for Brain repair and life span extension. Swimming therapy increases the expression of VGF and BDNF via down regulation of its target gene
Thereby, it may: 1) promote oligodendrocytes proliferation, 2) promote myelination of neurons, 3) revert neural damage, 4) confer protection against brain ischemia, 5) promote consolidation of hippocampal memory, 6) produce antidepressant like effects, 7) enhance glucose-stimulated insulin secretion, and 8) decrease stress hormones norepinephrine and epinephrine levels and thereby reduce blood pressure. And finally, as a consequence, prolong lifespan (figures 1).
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Together, this study suggests, for the first time, that swimming training may promote brain repair, alleviate neurodegenerative diseases (such as multiple sclerosis, cerebral ataxia etc.), and extend the lifespan of an individual. Thus, physicians may consider recommending patients suffering from cerebral ataxia and other neuronal pathologies of the central nervous system to under go swimming therapy.
Details of the Research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
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Undisclosed mechanistic Information: How does Swimming training increase the expression of VGF and BDNF, promote brain repair and increase mammalian life-span?
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References:
Citation: Boominathan, L., Swimming as a therapeutic exercise for brain repair and Lifespan extension: Swimming therapy increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 14/April/2017, 7.50 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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