What we say:
Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Allergic rhinitis: Ampelopsin [AMP; also called dihydromyricetin (DHM)], a flavonoid mainly found in Ampelopsis grossedentata (commonly known as Mayeam) inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene
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From Significance of the study to Public health relevance:
Given that: (1) in any given year, nearly 20-30% of people are affected by Allergic Rhinitis; (2) most of the medications available today for allergic rhinitis treats only the symptoms, and provide temporary relief; (3) corticosteroid therapy for allergic rhinitis may have its own side effects; (4) the global economic cost spent in the treatment of allergic rhinitis is enormous, there is an urgent need to find: (i) a way to cure allergic rhinitis, without adverse side effects; (ii) a cheaper alternative to the existing expensive medications; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, allergic rhinitis.
From Research findings to Therapeutic opportunity:
This study suggests, for the first time, a natural product based therapy for Allergic Rhinitis. Ampelopsin [AMP], by increasing the expression of its target genes, it may: (1) inhibit GM-CSF levels; (2) decrease IL13Rα1 expression; (3) suppress eotaxin expression; and (4) inhibit mucus production (figs. 1-3). Thus, pharmacological formulations encompassing “Ampelopsin [AMP] or its analogues either alone or in combination with other drugs” may be used to control allergic rhinitis.
Figure 1. Ampelopsis Grossedentata. Ampelopsin [AMP], one of the main constituents of Ampelopsis Grossedentata, inhibits the development and progression of Allergic Rhinitis via up regulation of its target gene.
Figure 2. The chemical structure of Ampelopsin (AMP) . AMP can be isolated from”Mayeam” . The leaves and stems of Mayeam are used to make a herbal tea generally known as Tujia God/heaven tea. The average lifespan of those who consume this tea regularly is 89 years; and this could perhaps be attributed to its insulin- secreting and neuroprotective property.
Figure 3. The Ampelopsis Grossedentata constituent Ampelopsin (AMP) as an anti-allergic rhinitis agent
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How does Ampelopsin (AMP) decrease the expression of GM-CSF/L13Ra1/eotaxin to inhibit allergic rhinitis?
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References:
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Citation: Boominathan, L., Natural product-derived therapy for Allergic rhinitis: Ampelopsin [AMP; also called dihydromyricetin (DHM)], a flavonoid mainly found in Ampelopsis grossedentata (commonly known as Mayeam) inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 7/May/2017, 11.45 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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