Introduction:What they say:
A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows that “Deubiquitination and Stabilization of PD-L1 by CSN5.” This study was published in the 12 December 2016 issue of Cancer cell (one of the best journals in Cancer Science with an impact factor of 23.523) by Prof Mien-Chie Hung, Lim SO and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Swimming training-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Swimming training inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene
What is known?
It has recently been shown that blocking cell surface receptor PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year recently.
From Research Findings to Therapeutic opportunity:
Swimming training, by decreasing the expression of its target gene, it may diminish the expression of PD-L1 (fig. 1). Thereby, it may: (i) inhibit inflammatory TNFα signaling; (ii) decrease the number of tumor-infiltrating lymphocytes and macrophages; (iii) increase T-cell anti-tumor immunity; (iv) decrease tumor burden; and (v) increase survival of patients with breast cancer (fig. 1).
Figure 1. Mechanistic insight into how Swimming training enhances the efficacy of cancer immunotherapy. Swimming training , by decreasing the expression of PD-L1 in cancer cells, it augments T-cell mediated anti-tumor immunity
Thus, swimming training may be advised for cancer patients to (i) inhibit the progression of tumors; and (ii) enhance the efficacy of Cancer immunotherapy. Together, oncologists may consider recommending their cancer patients to undergo swimming therapy.
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Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How Swimming training inhibits the expression of PD-L1 and augments anti-tumor immunity
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# Research cooperation
References:
Citation: Boominathan, L., Swimming training-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Swimming training inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 16/May/2017, 11.41 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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